Lecture 7: Esophagus and Stomach Histology Flashcards
What is the first part of the GI tract according to Furth?
The brain
Thinking about the eating activates shit
What is the function of stomach and function?
- motility
- barrier
Stomach = breakdown, hormone production and intrinsic factor
What is the epithelium of esophagus?
Stratified squamous
What type of epithelium lines the FETAL esophagus? Significance?
Ciliated COLUMNAR
Same epithelium as the trachea so it shows the common derivation of trachea and esophagus
Tracheo-esophageal fistulas then can occur
Where is the last place that you can find salivary glands?
Esophagus
What types of glands can be found in esophagus?
Salivary glands
Provides lubrication and enzymes like amylase
What are developmental abnormalities of esophagus?
- atresia
- fistula (tracheal-esophageal)
- Duplication cyst
- Inlet Patch
What is a duplicatioin cyst?
Rare congenital malformations of GI tract
Duplication of the segment to which it is adjacent
Can compress the airweay
What is an inlet patch?
A congenital anomaly when gastric mucosa is present at the end of what should be the esophagus
Can lead to esophagitis when acid is secreted by the gastric mucosa
Can actually be any type of mucosa
No biologic significance in patient
What is esophagitis?
Injury to the mucosal lining of the esophagus
Neutrophils and eosinophils are there
Lymphocytes are NORMAL
Why are there lymphocytes normally there in esophagus?
Because it is part of the mucosal associated lymphoid tissue (MALT)
What are the etiologies for esophagitis?
Allergy Pill Crohns Trauma REFLUX And a shitload more
What causes reflux esophagitis?
Failure of gastro-esophageal sphincter and gastric contents come up (bile and HCl)
Why does it matter as to the “type” or etiology of esophagitis a person may have?
Because it helps with treatment
Viral inclusions vs. neutrophils vs. fungus
Such as CMV
What are the histological/gross characteristics of eosinophillic esophagitis?
Histology = eosinophils Gross = striped tiger like appearance
What are skin disorders that present as esophagitis?
- Pemphigus
- Pemphigoid
- Lichenoid reactions
Why does skin shit affect esophagus?
Because skin and esophagus have the same epithelium
What is pemphigus?
A skin disease in which watery blisters form on the skin
What is one of the most common causes of dysphagia?
A Schatzki Ring
Ingrowth of the squamous epithelium that blocks shit
What is achalasia?
HYPERmotility disorder
Lower esophageal sphincter is tight and won’t open or relax
Leads to squamous cell carcinoma progression
Esophagus will enlarge due to the blockage
What happens in connective tissue disorders like scleroderma?
Selective atrophy of inner circular muscle layer
Presents with Raynaud’s
What is a Mallory Weiss tear?
When you rip the distal esophagus causing massive bleeding
Happens after wrenching vomiting