Lecture 7 - Asymmetry and Cancer Stem Cells

Question 1

There is a strong correlation between the activity of stem cells in a tissue and the life-time risk of that tissue to develop cancer
TRUE OR FALSE

Answer 1

TRUE

Question 2

Stem cells can be the “cell-of-origin” of cancer

TRUE OR FALSE

Answer 2

TRUE

Question 3

Symmetric Cell Division:

Answer 3

2 progenitors
OR
2 differentiated cells

Question 4

Asymmetric Cell Division:

Answer 4

1 progenitor
AND
1 differentiated cell

Question 5

Stem Cells divide rapidly

TRUE OR FALSE

Answer 5

FALSE

Stem Cells are mostly quiescent, they rarely divide

Question 6

Transient Amplifying cells divide rapidly

Answer 6

TRUE

Question 7

Tumours can display heterogeneity of cell types

Answer 7

TRUE

Question 8

Cancer Stem Cells:

Answer 8

Single cells that can generate heterogenous tumours

Rare
Slow-Dividing
Have Stem Cell Properties

Question 9

Cancer Stem Cell Hypothesis:

Answer 9

Tumour growth is driven by rare and slow dividing cells with stem cells properties: Cancer Stem Cells

Question 10

Cancer Stem Cells are ONLY derived from stem cells

TRUE OR FALSE

Answer 10

FALSE

They can also be derived from progenitors cells and differentiated cells

Question 11

Failed Asymmetric cell division causes tumour growth

TRUE OR FALSE

Answer 11

TRUE

Mutation analysis in Drosophila finds that failed asymmetric cell division is linked to tumour-like growth