Lecture 6: Rheum & MSK Flashcards
3 Requirements for Dx of Juvenile Arthritis (JIA)?
- Evid of joint inflammation
- CHRONIC arthritis (> 6 wks)
- Sxs must have been present at < 16 yrs old
4 signs on PE indicating chronicity of Juvenile Arthritis
- Synovial thickening
- Contracture
- Bony proliferation
- Limb length discrepancy
Definition of Systemic Juvenile Arthritis/Still’s Dz
(subset of JIA)
What is the typical fever pattern in this dz?
Systemic inflammation BEFORE onset of arthritis
daily fever spike of > 39 C –> quickly goes below baseline
- feel fine b/t spikes
4 characteristics of the rash a/w Systemic Juvenile Arthritis/Still’s Dz?
- at peak of fever
- Erythematous maculopapular rash on trunk/extremities
- Migrates + fades quickly
- Dermatographia
- Main thing seen on labs a/w Juvenile Arthritis?
- What other lab results a/w JIA?
- What is NOT seen in kids in JIA labs?
- ANA (anti-nuclear Abs)
- Evid of systemic inflam (C reactive protein, WBCs, etc)
- Rheumatoid factor NOT seen in kids w/JIA
Which type of JIA has the highest prevalence of ANAs
- what is only prob w/ANAs for Dx?
When is Rheumatoid factor positive?
Oligoarticular JIA = most ANAs
Rheumatoid factor is positive in adol + adults w/ RA
What is lst line Tx for JIA?
- when should you switch pts to something else?
- what are the other 3 Tx options?
1st line = NSAIDs
- switch if not working in 1-2 wks
other Tx options
- Hydroxychloroquine
- Methotrexate
- Biologics (-mabs, etc)
What is the main complication of JIA?
Therefore kids w/what dz are required to be screen for this?
Uveitis
- note: MC cause of blindness in kids and often Asx
screening required for ALL kids w/chronic arthritis
3 cutaneous manif a/w Juvenile Dermatomyositis (JDM)?
- Heliotrope rash –> rash around eyes
- Gattron’s papules (fingers)
- Periungual erythema
Main sign a/w Juvenile Dermatomyositis?
What it is/what is it d/t?
Other signs
- Calcinosis/calcif of muscles
- Lipotrophy
Gower’s sign = child must must hands to “walk own body up from lying prone position to stand
- d/t lack of strength of in hips/thighs (proximal muscle weakness)
What 3 things provide evid of inflammatory myositis in JDM?
- Muscle enzymes elevated
- Muscle Bx
- MRI
What is the initial Tx for JDM?
- other tx options?
start w/prednisone
- other: Methotrexate, Cyclophosamide
2 Cutaneous manifestations of Henoch-Schonlein Purpura (HSP)?
note: dz peaks in winter
- Palpable purpura = MC
2. Edema (hands, feet, face, scrotum)
MC areas and appearance of Palpable Purpura in HSP?
MC in dependent areas –> bac of legs/butt
appearance = petechia/macules/urticaria –> ecchymosis
4 things a/w Arthralgia/arthritis see in Henoch-Schonlein Purpura?
- in large LE joints
- v. painful–> refuse to bear wt
- joint swelling but usu no erythema
- Transient
3 signs a/w GI involvement in Henoch-Schonlein Purpura?
Note: onset = w/in 1wk -1 mo of rash
- colicky abd pain
- heme (+) stools
- intestinal perforation
What is the renal involvement in Henoch-Schonlein Purpura (HSP) d/t? 3 things seen w/it?
Note: onset = w/in 1-3 mo of rash
d/t acute glomerular nephritis
- hematuria/proteinuria
- HTN
- +/- renal failure
2 things seen on labs a/w Henoch-Schonlein Purpura
- what cannot be present?
Results on pathology?
- Elevated inflam markers
- Normocytic, normochromic anemia
- CANT HAVE THROMBOCYTOPENIA
Pathology –> IgA deposition w/Leukocytoclastic vasculitis