Lecture 4: Endocrine

Question 1

Three types of BENIGN short stature

Answer 1

1. Constitutional Growth Delay
2. Familial Short Stature
3. Idiopathic Short Stature

Question 2

S/s a/w Constitutional Growth Delay?

Answer 2

1. FHx of late bloomers
2. Growth pattern = deceleration
3. DELAYED bone age

Question 3

S/s a/w Familial Short Stature?

Answer 3

1. Ht/wt proportional
2. Deceleration in growth pattern at 6-18 mo
3. NORMAL bone age

Question 4

biggest difference b/t benign vs pathologic short stature?

Answer 4

benign = normal growth velocity
Pathologic = ABNORMAL growth velocity

Question 5

workup for ____________.

1. CMP
2. Sed rate or CMP
3. Bone age
4. Thyroid fx tests
5. chrom on females
6. IGF1 & IGFB3

Answer 5

Pathologic/concerning short stature

Question 6

3 endocrine causes of pathologic short stature

Answer 6

1. HYPOthyroidism
2. Untreated precocious puberty
3. GH defic

Question 7

3 s/s of GH defic in neonates

2 s/s of GH defic in kids

Answer 7

Neonates

1. midline defects
2. hydrocephalus
3. HYPOglycemia

kids

1. decreasing growth velocity
2. LOW IGF1 & IGFBP3 or GH

Question 8

biggest diff b/t GH defic neonates and kids

Answer 8

neonates - GH = irrelevant in 1st yr of life

kids - GH given = rapid incr in growth velocity

Question 9

What genetic syndrome is a/w pathologic short stature

Answer 9

Turner Syndrome