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PCL469 > Lecture 6: Prostaglandins and Anti-inflammatory Agents > Flashcards

Lecture 6: Prostaglandins and Anti-inflammatory Agents Flashcards

1
Q

IL-1ß

A

systemically
- promotes fever and production of IL-6

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2
Q

TNF-alpha

A

systemically
- promotes fever
- mobilization of metabolites
- shock

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3
Q

IL-6

A

lymphocyte activation, increased Ab production
- fever

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4
Q

IL-12

A
  • activates NK cells induces differentiation of CD4 t cells into Th1 cells
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5
Q

Activated macrophages secrete a range of cytokines

A

IL-1ß, TNF-alpha, IL-6, CXCL8, and IL-12

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6
Q

hydroxyprostaglandin dehydrogenase

A

enzyme that acts on the C15 hydroxy group of prostaglandins to convert to a ketone

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7
Q

carbonyl reductase 1

A

reduces the ketone at C9 (if there is one)

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8
Q

PGE2

A

vessels
- vasodilation

bronchi
- bronchodilation

stomach
- inhibition of gastric acid secretion
- motility

uterus
- contraction and parturition

HPA axis
- increase in hypothalamic and pituitary hormone secretion

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9
Q

PGE1

A

Platelets
- anti-aggregation

Intestines
- motility
- nausea and diarrhea

Kidney
- filtration and renal blood flow

HPA axis
- increase in hypothalamic and pituitary hormone secretion

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10
Q

PGF2

A

vessels
- vasoconstriction

uterus
- contraction and parturition

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11
Q

PGF2-alpha

A

bronchi
- bronchoconstriction

Intestines
- motility
- nausea and diarrhea

stomach
- motility

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12
Q

PGI2

A

Vessels
- vasodilation (most active PG at this)

platelets
- anti-aggregation

Bronchi
- bronchodilation

stomach
- inhibition of gastric acid secretion

Kidney
- filtration and renal blood flow

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13
Q

PGD2

A

vessels
- vasodilation

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14
Q

PGs acting on vessels

A
  • vasoconstriction: PGF2 (eff)
  • vasodilation: PGI2, PGE2, PGD2 (DIE)

all 2s

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15
Q

PGs acting on platelets

A
  • anti-aggregation: PGE1, PGI2

(one e, two i’s in the word)

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16
Q

PGs acting on bronchi

A
  • bronchoconstriction: PGF2-a
  • bronchidilation: PGE2, PGI2
17
Q

PGs acting on intestines

A
  • nausea, diarrhea: PGE1, PGF2-a
  • motility: PGE1, PGF2-a

same for both which makes sense

18
Q

PGs acting on the stomach

A
  • inhibition of gastric acid secretion: PGE2, PGI2
  • motility: PGE2, PGF2-a
19
Q

PGs acting on the uterus

A

contraction and parturition: PGE2, PGF2

20
Q

PGs acting on the kidney

A

filtration and renal blood flow: PGH2, PGE1, PGI2

21
Q

PGs acting on the hypothalamic and pituitary axis

A

increase in hypothalamic and pituitary hormone secretion: PGE1, PGE2

22
Q

Epoprostenol

A

PGI2

23
Q

Misoprostol

A

analogue of PGE1

24
Q

Dinoprostone

A

PGE2

25
Q

Alprostadil

A

PGE1

26
Q

Dinoprost

A

PGF2alpha

27
Q

carboprost

A

PGF2alpha analogue

PCL469 (18 decks)

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