Lecture 6 - Integration of Metabolism Flashcards
Describe the relationship between skeletal fat and CHO oxidation
Reciprocal relationship
How does increasing FFA availability effect CHO oxidation?
Increasing FFA availability inhibits CHO oxidation at multiple sites
How does increasing glucose availability effect fat oxidation?
Increasing glucose availability inhibits fat oxidation at CPT1
What is the suggested mechanism for glucose availability inhibiting fat oxidation?
Free carnitine depletion
What is the effect of carnitine supplementation on CHO and fat oxidation and exercise performance?
No effect
Describe the effect of carnitine supplementation on muscle carnitine content
No effect
Describe the implications of inulin resistance
- Impaired ability to stimulate glucose oxidation
- Impaired ability to stimulate microvascular perfusion
- Impaired ability to stimulate AA uptake to muscle cells
- Impaired ability to inhibit muscle protein breakdown
How is insulin resistance brought about?
Increased energy uptake
Physical inactivity
Being overweight/obese
What is the direct precursor of type 2 diabetes?
Insulin resistance
How is type 2 diabetes defined?
Resulting from a defect in both insulin sensitivity and insulin secretion
What percentage of type 2 diabetics are obese?
80%
How many people in the UK have diabetes and how many of them have type 2?
2.75 mill and 2 mill
How much of the NHS budget do type 2 diabetics account for?
Tenth
What are the complications of diabetes?
Amputation
Heart disease
Kidney failure
Blindness
What is the cause of metabolic disease?
Disregulation in fuel metabolism
