Lecture 6: Dyslipidemia Flashcards
4 groups of statin
In CAL the HIGH DR was MODERN Cholesterol Rx (Age > 20) if: 1. A: known ASCVD 2. L: LDL > 190
MOD
- D: diabetes 40-75 with LDL 70-189
- Risk: > 7.5% ASCVD in 10 years
name the HIGH intensity statin
HIGH
Atorva 80
Rosuva 20
fasting sample needs
Fasting samples may be required if nonfasting triglyceride levels are greater than 440 mg/dL
secondary causes of dyslipidema
hypothyroidism, diabetes, and glucocorticoid use.
secondary causes of hypertryglycercide
excessive alcohol use, hypothyroidism
exogenous estrogens, chronic kidney disease
use of protease inhibitors
statin related side effects
risk factors for statin-related adverse effects, including age older than 75 years, impaired kidney or liver function, muscle disorders, and use of drugs affecting statin metabolism (calcium channel blockers, fibrates, protease inhibitors, amiodarone, macrolide antibiotics
name the PCSK9 inhibitors
alirocumab
evolocumab
indication for PCSK9 inhibitors
clinical ASCVD and unacceptably high LDL cholesterol levels while already taking maximally tolerated statin therapy and for patients with certain forms of familial hypercholesterolemia
indication ezetamide
Ezetimibe is the preferred nonstatin agent in patients with or without diabetes with LDL cholesterol levels between 70 mg/dL (1.81 mmol/L) and 189 mg/dL (4.90 mmol/L) who are taking maximally tolerated statin therapy for primary prevention. Likewise, ezetimibe is preferred in patients with stable clinical ASCVD without comorbid conditions who require additional LDL cholesterol lowering
tx hypertryglyceride
fasting triglyceride level of 500 mg/dL, fibrates
metabolic syndrome definition
PHATS
Pressure >130/85 mm Hg HDL cholesterol Abdominal obesity Triglycerides ≥150 mg/dL Sugar ≥110 mg/dL
