Lecture 6 - Cystic Fibrosis

Question 1

Respiratory clinical features

Answer 1

Coughing
Frequent bacterial infections
Lung damage

Question 2

GIT clinical features

Answer 2

Failure to thrive
Chronic malabsorption (can't absorb fats, more difficult to absorb proteins)

Question 3

Mode of inheritance

Answer 3

Autosomal recessive

Question 4

A way to treat digestion problems

Answer 4

Take enzyme tablets

EG: Pancrease

Question 5

Suggested diet

Answer 5

High fat, high salt

Question 6

Below what lung functionality is a lung transplant suggested?

Answer 6

Below 30% function

Question 7

Proportion of CF neonates with meconium ileus

Answer 7

15%

Question 8

Proportion of CF patients with pancreatic insufficiency

Answer 8

85%

Question 9

Proportion of CF patients with chronic pancreatitis

Answer 9

40%

Question 10

Proportion of CF patients with diabetes

Answer 10

40%

Question 11

Reasons for CF infertility

Answer 11

In males: Vas deferens blocked –> fibrosis, atrophy
Congenital bilateral absence of the vas deferens (CBAVD)

Females: Mucus in vagina prevent sperm access
Anovulatory