Lecture 6 - Cholinergic Agonists Flashcards
______ receptors use ion channels
nicotinic
nicotinic affects ganglion of both ___ and ___
SNS
PNS
nicotinic affects _____ muscle
skeletal
Muscarinic receptors are _____ mediated
G-protein
What do muscarinic receptors affect ?
effector organs/tissues of parasympathetic
Sweat receptors on the ____ are adrenergic
palms
Sweat receptors everywhere else are ____
cholinergic (but still part of sympathetic system)
All preganglionic synapses are _____
cholinergic
Skeletal muscle works through ___ receptors
ACh
Does ACh cross the BBB
NO
-so there are no psychological effects
What does ACh activate?
- all autonomic ganglia (sympathetic and parasympathetic)
- skeletal muscle receptors
What does Pilocarpine do?
-very similar to ACh but it CAN penetrate BBB
What is pilocarpine the drug of choice for?
severe acute glaucoma (intraocular pressure)
-it causes immediate opening of drainage system of the eye
-also used for fixed focus
What does AChE do? (acetylcholinesterase)
degrades Ach in the synapse
What will inhibition of AChE do?
It will increase the activity of ACh in the synapse
i. e. it will have a cholinergic agonist effect
- increased activation of the parasympathetic NS
What is myasthenia gravis?
it is autoimmune destruction of Ach receptors at NMJ (neuromuscular junction)
What type of drugs can help with myasthenia gravis?
drugs which increase ACh activity can aid the symptoms
(no underlying pathology)
- this is a short term solution because you are only increase Ach of the receptors that are left
- eventually all receptors will die because that is a characteristic of this condition
What is alzheimer’s disease?
cholinergic neurons in brain undergo reduced activity and then die