Lecture 6 - Cardiac Medications Flashcards
What medications would a person with hypertension take?
- B-blockers
- ACE inhibitors
- Diuretics
- CCB’s
- Alpha blockers
What medications would a person with CHF take?
- B-blockers
- ACE inhibitors
- Diuretics
- Digitalis
- Vasodilators
What medications would a person with MI take?
- B-blockers
- Aspirin
- Antihyperlipidemics
- Lasix
What does nitric oxide (NO) do?
- Causes vasodilation
- Reduces Preload and afterload (by increasing venous capacitance)
- Lowers heart wall stress
What are some common side effects of NO?
- HA
- Facial flushing
What are some serious side effects of NO?
- Syncope
- Hypotension
What do B-blockers do?
Reduces cardiac work (o2 demand) by:
- Reducing HR
- Reducing Contractility
What do B1 receptors do when active?
Heart: Increase 1. HR 2. Conduction 3. Contraction 4. Ejection Fraction Others: Increase 1. Renin release 2. Hunger
What do B2 receptors do when active?
- Relaxes smooth muscle in:
- Bronchus and Bronchioles
- Uterine muscle - Contracts urethral sphincter
- Increases renin release
- Stops insulin release
What do B2 receptors do when active?
- Relaxes smooth muscle in:
- Bronchus and Bronchioles
- Uterine muscle - Contracts urethral sphincter
- Increases renin release
- Stops insulin release
- Stimulates Gluconeogenisis and glycolysis
- Lipolysis
- Thick Saliva
What is the difference between Selective and Non-Selective B-blockers?
Selective (B1) cause fewer peripheral effects compared to Non Selective (B1 and B2) drugs
What type of B-blocker may a patient be taking if you notice they are coughing a lot?
Non Selective B-Blockers because inhibition of B2 receptors causes bronchospasms due to smooth muscle contraction.
What type of B-blocker may a patient be taking if you notice they are coughing a lot?
Non Selective B-Blockers because inhibition of B2 receptors causes bronchospasms due to smooth muscle contraction.
What do B-Blocker drugs end with in their names?
“olol”
For example: Propranolol
How do B-Blockers decrease sympathetic activity?
- Decreases calcium uptake
- Impairs CICR