lecture 6 Flashcards
What distinguishes electrical synapsing?
1) mediated by direct intercellular coupling
2) has no synaptic delay.
3) mediates excitation only
4) Less prevelant in adults but its used molsty between cardiac and smooth muscles
What distinguishes chemical synapsing?
1) Requires (T)
2) has synaptic delay
3) mediates inhibition or excitation
4) Synaptic efficacy can be modulated.
What are gap junction specialized channels called? ones that mediate electric synapsing.
They’re called connexons
Whats the difference in structure between excitatory bouton vs an inhibitory bouton?
-Excitatory boutons have postsynaptic density while inhibitory boutons lack them.
Whats the difference between CNS synaptic clefts and NMJs?
The clefts are much thinner in CNS
What does the botulinum toxin targets in the exocytosis mechanism?
it targets SNARE proteins.
What are the families of ligand gated channels?
B1 which includes ACh, GABA and glycine receptors
-Has 5 subunites
C1 includes glutamate receptors.
-Has 3 subunits
Whats the major excitatory synaptic transmitter in the CNS? How can you terminate that transmitter?
Glutamate. Its terminated by reuptake by terminal or uptake by glial cells.
What are the 3 kinds of ionotropic glutamate receptrors?
1) AMPA:
2) NMDA receptors: permeable to sodium potassium and calcium. Its a channel and a signaling molecule.
What is the distinguishing features of AMPA?
only premeable to sodium and potassium which is similar to the nicotinic receptors. So Activation will flow in the cell and potassium will flow out (EPSP)
