Lecture 6 Flashcards
Name the common ear infections
Acute and chronic otitis media, vertigo, sensorineural hearing loss, tinnitus
Why is it hard to deliver drugs to the inner ear?
Because of the barrier between the blood and fluid filed spaces
What is ear wax made up of?
Sebum, dead skin cells, sweat and dirt
What is the function of ear wax?
Protective coating and traps particulates
What are the causes of impaction?
Narrow auditory canal, overproduction of cerumen or cotton buds
How is ear wax removed and how should it not be removed?
Removed using drugs to loosen ear wax and DO NOT USE EAR BUDS
Name the two types of tympanic membrane perforations
Acute and chronic
What does the lamina propria provide?
Collagen rich environment and provide structural support
Name the 4 non-invasive delivery systems
Hydrogels, chemical permeation enhancers, nanocarriers, peptides
Name the 4 invasive delivery systems
Hydrogels, nanopeptides, ultrasound, pump/ catheter
Define cochlear
Auditory organ
Define vestibular system
Organ of balance
What is the healing process of a tympanic membrane perforation?
Epidermis closes first
flooded with cells and GFs
Fibrous layer reconstruction - new collagen synthesised
REDUCE size of the wound - needs blood supply, small blood vessels started to form
Making a new matrix fibres pulled together
Maturation - remodelling and reorganisation
How is the ear canal different in infants?
straighter and narrower to help administer drug pull tip of the ear
