Lecture 5 - Study Guide

Question 1

allosteric transitions in ____ can regulate ____ ____ or ___ ____

Answer 1

proteins can regulate complex binding or catalytic behavior

Question 2

enzymes ____ rates or determine ___ ____ (____ ____)

Answer 2

accelerate rates or determine product distributions (relative rates)

Question 3

3 major mechanisms of catalysis:

___ ___ ____

controlling ____/____

direct ___ ____ participation

Answer 3

transition state stabilization

controlling proximity / orientation

functional group participation

Question 4

for dual susbtrate lineweaver-burk plots, ___-____ analysis can be applied

Answer 4

inhibitor-like analysis can be applied

Question 5

allosteric modulation can occur from a ___ ___ site or from a ___-___ ____ (___ modulator - ___- or ___ inhibitor)

Answer 5

second substrate site or from a non-substrate modulator (negative modulator - non- or uncompetitive inhibitor)