Lecture 5: Neuro Cases 2 Flashcards

1
Q

What is a tremor?

A
  • An involuntary, rhythmic, oscillatory movement of a body part
  • Most common movement disorder seen in primary care clinics
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2
Q

What are the major classifications of tremors?

A
  • Resting
  • Action
  • Enhanced physiologic
  • Essential
  • Parkinsonism
  • Cerebellar
  • Psychogenic
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3
Q

Describe a resting temor.

A
  • Occurs in body part that is relaxed and completely supported against gravity
  • Enhanced by mental stress or movement of another body part
  • Diminished by voluntary movement of that body part
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4
Q

Describe an action tremor.

A
  • Postural tremor: maintaining a position against gravity
    • Ex: arm elevation
  • Isometric tremor: muscle contraction against a rigid stationary objects
    • Ex: making a fist
  • Kinetic tremor: associated with voluntary movement and includes intention tremor, which is produced w/ target-directed movement
    • Ex: reaching for a pen
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5
Q

Describe an enhanced physiologic tremor.

A
  • Everybody has an asymptomatic physiologic tremor
    • Low amplitude
    • High frequency at rest and during activity
  • Enhanced by anxiety, stress and certain medications
    • If patients have tremors that come and go with anxiety, medication use, caffeine intake or fatigue, they do not need further testing
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6
Q

Describe an essential tremor.

A
  • Most common pathological tremor
  • Most common in hands and wrists, can also affect head, LEs and voice
  • Usually bilatera
  • Can be inherited, tends to progress with age
    • •5% of those affected retire early or modify career path
  • Caffeine and fatigue exacerbate these tremors, alcohol can help symptoms
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7
Q

What is the most common form of Parkinson’s Disease?

A

Idiopathic Parkinson’s Disease (PD)

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8
Q

What is the classic “parkinsonian” tremor?

A

“Pill rolling” tremor

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9
Q

What is a classic symptom of Parkinson’s?

A

Bradykinesia: difficulty rising from a seated position, micrographia, reduced arm swing while walking

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10
Q

Describe a cerebellar tremor.

A
  • Low-frequency, slow-intention or postural tremor
  • Caused by MS with cerebellar plaques, stroke, or brainstem tumors
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11
Q

What is particularly challenging about diagnosing a psychogenic tremor?

A

It can be very difficult to differentiate from organic tremor

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12
Q

What are some telltale signs of a psychogenic tremor?

A
  • Abrupt onset
  • Spontaneous remission
  • Changing tremor characteristics
  • Increase with attention and extinction with distraction
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13
Q

What would a family history of neurologic disease suggest?

A

Genetic component

(common in essential tremors)

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14
Q

What would a tremor in an older patient with gradual onset suggest?

A

Parkinson’s Disease or Essential Tremor

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15
Q

What would a sudden onset tremor most likely indicate?

A
  • Psychogenic tremor
  • Related to medication use or toxin exposure
  • Brain tumor
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16
Q

What are the common symptoms associated with Parkison’s Disease?

A
  • Tremor
  • Decreased arm swing
  • Soft voice
  • Sleep disturbances
  • Decreased sense of smell
  • Symptoms of autonomic dysfunction
  • Decreased facial expression
  • Malaise
  • Depression/anhedonia
  • Slowness in thinking
17
Q

What is the difference in writing patterns between PD and Essential tremor?

A
  • Parkinson’s Disease: micrographia
    • small, illegible
  • Essential tremor: tremulous
    • large, illegible
18
Q

What is dementia?

A
  • Loss of cognitive functioning and behavioral abilities that can interfere with a person’s daily life and activities
    • Memory
    • Language skills
    • Visual perception
    • Problem solving
    • Self-management
19
Q

What is the difference between major and minor neurocognitive disorders?

A
  • Major: signficiant cognitive disorder in at least domain interfering with daily living
  • Minor: modest cognitive disorder that does not interfere with daily living
20
Q

When treating a patient suspected to have dementia, what should the history include?

A
  • Timeline of symptom presentation
  • Speed of progression
  • Medication
  • Recent hospitalizations
  • Infection
21
Q

What are some reversible causes of dementia?

A
  • Hypothyroidism
  • Vitamin deficiencies
  • Intracranial tumors
  • Normal pressure hydrocephalus
  • Depression
  • Hypoperfusion from heart failure
22
Q

What are some screening tests for cognitive impairment?

A
  1. Mini-cog
  2. ASCERTAIN Dementia 8 Item Informant Questionnaire
  3. General Practioner Assessment of Cognition
23
Q

Describe a Mini-Cog test.

A
  • Patient asked to repeat three unrelated words
  • Peform a clock drawing test
  • Recall three words
24
Q

Describe a ASCERTAIN Dementia 8 Item Informant Questionnaire.

A
  • Screens for major and minor neurocognitive disorders
  • If patient score is >2, cognitive impairment more than likely
25
Q

If any of the screening tests are positive, what is the next step for dementia patients?

A
  • Mini-Mental State Examination
  • Montreal Cognitive Assesment
  • SLU Mental Status Examination

Followed by:

  • Geriatric Depression Scale
  • Lab evaluation and neuroimaging