Lecture 5 | Myostatin & Anorexia

Question 1

Goal myostatin pathway

Answer 1

Pathway that limits muscle protein synthesis/ increases muscle protein breakdown

Question 2

Steps of the myostatin pathway

Answer 2

1. Myostatin binds to activin A (ACTRIIB) receptor
2. Smads inhibit AKT and mTOR (inhibit synthesis)
3. Smads activate FOXO (stimulate breakdown)

Question 3

Alternative pathway of myostatin pathway

Answer 3

Bone morphogenetic protein (BMP) pathway
Induces bone formation and stimulates muscle protein synthesis
Share SMAD4

Question 4

Blockage of myostatin pathway with

Answer 4

• Myostatin or myostatin receptor antibodies
• ACE-031
• Follistatin = natural regulator of myostatin

Question 5

Food regulating nuclei

Answer 5

NPY-AgRP: orexigenic = stimulates food intake

POMC-CART: anorexigenic = inhibits food intake

Question 6

Drivers of IL-6 secretion by hypothalamic cells

Answer 6

LPS and PGE2 (=prostaglandin)