Lecture 5: Clinical trials in respiratory disease - critical appraisal

Question 1

what is PICOT?

Answer 1

criteria for evidence (external validity)

population 
intervention
comparator
outcome
timing

Question 2

What is stratified randomisation?

Answer 2

subjects randomised within strum to which they belong (e.g. by country, smoking status, education status etc…)

Question 3

Null value for ratios is?

Answer 3

1

Question 4

Null value for absolute difference?

Answer 4

0

Question 5

What is a TII (beta) error

Answer 5

study concludes no treatment effect but in fact there IS a treatment effect

Question 6

What is a T1 (alpha) error?

Answer 6

Study concludes there is a treatment effect but in fact there is NO treatment effect

Question 7

T/F the bigger the likelihood of outcome, the smaller the NNT

Answer 7

True - more likelihood = less people NNT for an effect