Lecture 5 Flashcards

1
Q

Cell Fate

A
  • Asymmetric division: child cells born with different fates
  • Symmetric division -> signal: Child cells born same, acquire different fates
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2
Q

Asymmetric Division

A
  • Cell fate markers unevenly distributed before division
  • After division, one child cell inherits more of cell fate marker
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3
Q

Lateral Inhibition

A
  • Lateral inhibition creates a pattern of isolated differentiated cells in a field of relatively undifferentiated cells
  • Active notch inhibit cell specialization
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4
Q

Diffusible signals

A
  • Morphogens are diffusible signals that affect cell differentiation -> diffuse and act on nearby cells
  • Cells respond to morphogenetic by taking on new cell fate
  • Cells can respond differently to same morphogenetic given at different concentrations
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5
Q

Cell differentiation

A
  • Totipotent cells: Become any cell type
  • Pluripotent: Cells can become any adult cell type
  • Multipotent: Cells can become multiple cell types
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6
Q

Regulatory Hierarchies

A
  • Same morphogenetic produced by cell type C can have different effects on cell types A and B
  • Divide body into segments
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7
Q

Hox gene

A
  • Hox gene expressed in different segments and specify different body parts
  • Hox genes organized on chromosomes in order of expression
  • Hoox genes determine which body parts will determine from a segment
  • Humans have 4 copies of hox complex
  • Encode transcription factors
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