Lecture 12 Flashcards
1
Q
Classification of cancers
A
- Carcinoma: cancers developing from epithelial cells
- Sarcoma: Cancers developing from connective and muscle tissue
- Leukemia: Cancers developing from blood cells
2
Q
Cancer-critical genes
A
- Oncogenes: over-activation, dominant mutation
- Tumor-suppressor genes: inactivation, recessive mutation
3
Q
Ras mutation
A
- Point mutation disrupt GTPase activity of Ras
- Signaling pathway always on
4
Q
Myc overexpression
A
- Myc oncogene promote cell cycle progression
- Increase G1-Cdk activity, expression, increase E2F expression, decrease Rb activity
5
Q
Chromosomal rearrangements
A
- Abl is tyrosine kinase involved with signaling
- Bar-Abl fusion called Philadelphia component
- Hyperactivity of All
6
Q
Loss of p53
A
- p53 tumor suppressor activated under many different stress conditions
- p53 leads to apoptosis
- Loss of p53 allows cell to survive
7
Q
Gleevec
A
- Gleevex specially targets Bcr-Abl kinase -> blocks oncogenic kinase
