lecture 5

Question 1

epidermolysis bullosa

Answer 1

a group of inheritable disorders, characterized by epidermal gragiligity (blisters and erosion)- can be caused by mutations in adaptive proteins, integrins, multiadhesive proteins, collagen,

Question 2

cell adhesion molecules

Answer 2

selectins, cadherins, integrins

Question 3

slectins

Answer 3

• bind glycoproteins
• cell-matrix interactions
• heterophlic binding
• divalentcation dependent
• important role in host demesne mechanisms
• carbohydrate binding

Question 4

cadherins

Answer 4

• bind other cadherins
• cell-cell interactions
• homophobic binding
• cell-cell interactions

Question 5

ntegrins

Answer 5

heterophilic binding
- cell adhesion molecule

Question 6

types of Selectins

Answer 6

E-selectin (endothelial)
L-seleectin (leukocyte)
P-selectin (platelet)

Question 7

Ig superfamily

Answer 7

• calcium independent
• cell-cell interactions
• characteristic immunoglobulin domains

Question 8

cadherinsbind laterally through

Answer 8

the help of calcium, they will aggregate an bind to each other- u can have lateral and intercellular interactions

Question 9

subclasses of cadherins

Answer 9

P cadherin, n CADHERIN, e CADHERIN

Question 10

P cadherin

Answer 10

placental

Question 11

N cadherin

Answer 11

neural

Question 12

E cadherin

Answer 12

epithelial

Question 13

what properties affect cell-cell adhesion strength

Answer 13

• binding affinity
• spatial distirbution
• activity state of adhesion molecules
• external forces surrounding the cells

Question 14

binding affinity

Answer 14

if Ca is present, there is good binding affinity

Question 15

spatial distirbtuion

Answer 15

• lots of acdherins in a spot would increase binding affinity

Question 16

external forces surrounding the cells

Answer 16

• for example when faced with forces like friction, the cell would respond by generating more adhesion molecules bc they are needed

Question 17

activity state of adhesion molecules

Answer 17

when intracellular regions are phosphorylated, this increases or decereases the association between proteins

Question 18

what are the two classes of anchoring junctions

Answer 18

• cell-matrix
• cell-cell

Question 19

what are teh cell-matrix anchoring junctions

Answer 19

hemidesmosomes
focal adhesions

Question 20

what are the cell-cell anchoring junctions

Answer 20

adherens junctions,
desmosomes

Question 21

hemidesomoesomes

Answer 21

• intermediate filaments

Question 22

focal adhesions

Answer 22

actin

Question 23

adherens junctions

Answer 23

actin (e..g E-cadherin)

Question 24

desmosomes

Answer 24

• intermediate filaments
• have “desmo” prefix

Question 25

examples of desmosomes

Answer 25

desmoglein, desmocollin

Question 26

when intermediate filaments are found at the side of the cell, what kind of junction do they form?

Answer 26

hemidesmosomes

Question 27

when intermediate filaments are found at teh bottom of the cell, what kind of junction do they form

Answer 27

desmoesomes

Question 28

cahderins + actin

Answer 28

adherens junctions (cell-cell)

Question 29

cadherins + if

Answer 29

desmosomes

Question 30

occluding junctions aka

Answer 30

aka tight junctions

Question 31

occluding junctions

Answer 31

- prevent small molecule passage - can make a water tight barrier - found in polarized epithelia - will alter leakiness depending on type of claudins/poccludings to allow or not allow for paracellular transport (in between the cells vertically)

Question 32

what kind of Claudia is found in the proximal tubule

Answer 32

permissive to K and water - Claudia 2

Question 33

what kind of Claudin is found in the distal tubule

Answer 33

NOT PERMISSIVE to anything (distal tubule) - claudin 4 and 8

Question 34

what kind of Claudin is in the ascending loop of hence

Answer 34

Claudin 16 - permissive to mG

Question 35

gap junctions aka

Answer 35

communicating junctions

Question 36

gap junctions

Answer 36

-mediate passage of ions.solutes or electrical signals from one cell to its partner

Question 37

what is the building block of a gap junction

Answer 37

connexin

Question 38

1 connexon/hemicahnnel is made up of

Answer 38

6 connexins and a full channel is made up of 2 connexions and 12 connexins