Lecture 3 Flashcards
1
Q
ECM
A
- holds cells and tissues together
- organized environment for cells to move and intearct
- bidirectional transfer of information
- regulates proliferative capacity, differentiation and survival what
- structural functions in bone and teeth
- tensile strength in tendons
- transparent matrix for sight in the cornea
- controls cell behaviour
2
Q
what is an example of the ECM contributing to the proliferative capacity
A
- for ex liver cells have a great proliferative capacity, cells will proliferate until they fill the cavity using cell-cell contact
3
Q
what is the ECM made up of
A
- meshwork of proteins and polysaccharides
- secreted by ells into the spaces around them
4
Q
features of epithelial cells
A
- have an apical and basal surface
- located in the epidermis
5
Q
fibroblasts
A
- don’t use cell-cell contacts
- has no basal-apical polarity, but polarity of movement
- ## contact the extracellular matrix with focal adhesions
6
Q
what surface of the epithelial cell associates with the basal lamina
A
the basal surface associates with it,
7
Q
the basal lamina
A
is the extracellular matrix that supports the cell
8
Q
how are cells connected to adjacent cells
A
- specialized attachments like tight junctions, desmonosmes and gap junctions
9
Q
network-forming collagen is found in the
A
basement membrane, muscle, dermis, cornea and cartilage
