Lecture 4- Transport of lipids Flashcards
lipids are a diverse group of compounds
TAG
Fatty acids
Cholesterol
Phospholipids
Vitamine A, D, E, K (always do eat kitkats)
features of lipids
- Hydrophophic molecules (insoluble in water) –> problem for transport in blood
- Therefore transported in blood bound carrier
2% of lipids (fatty acids) are carried bound to
albumin –> limited capacity
98% of lipids are carried as
lipoprotein particles consisitng of:
- phospholipid
- cholesterol
- cholesterol esters
- proteins
- TAG
Typical plasma lipid conc ranges
structure of phospholipids
-
Polar (hydrophilic) head group
- Head group
- E.g. choline (classified according to polar head group (phosphatidylcholine)
- Phosphate and glycerol
-
Non-polar (hydrophobic) tail
- Fatty acids
unsatruates fatty acids tail (CIs bond) allowa
fluidity
what are micelles
single layer of phopsholipids- spherical
Liposomes
spherical phospholipid bilayer
some cholesterol is from the ………., most is synthesised in the …….
Some cholesterol from the diet, most synthesised in liver
Cholesterol role in the body
- Essential components of membrane (modulates fluidity)
- Precursor of steroid hormones
- Cortisol
- Oestrogen
- Aldosterone
- Testosterone
- Precursors of bile acids
cholesterol is transported around the body
as cholesterol ester (cholesterol with fatty acid group added)
cholesterol ester
cholesterol with fatty acid attached
lipoproteins
Micelles consisting of a single phospholipid sphere
- Transport lipid around the body
lipoprotein cargo
- TAG
- Cholesterol ester
- Fat soluble vitamins
structure of lipoproteins
Micelles
- Have integral or peripheral apolipoproteins in the phospholipid membrane- which define what sort of lipoprotein it is
how many classes of lipoproteins
5 distinct classes
name the 5 distinct classes of lipoprotein
- chylomicrons
- VLDL
- IDL
- LDL
- HDL
chylomicrons
transport dietary fat- TAG
VLDL
very low density lipids
fat made in the liver and exported in very low density lipoproteins
IDL
intermediate density lipoprotein
LDL
density lipoprotein
HDL
high density lipoprotein
diameter of liporptoeins
the less dense e.g. chylomicrons, the larger the lipoprotein
HDL most dense and smallest
particle diamter relationship to density
Particle diameter inversely proportional to density
Levels of lipoproteins in blood are of significant clinical importance
Density obtained by flotation ultracentrifugation