Lecture 4 - Small Bowel/IBD/anorectal Flashcards

1
Q
Crohn (CD) vs Ulcerative colitis (UC):
any portion of GI, usually terminal \_\_\_\_\_:
only colon:
transmural inflam:
only mucosal/submucosal:
A

CD (illeum);
UC;
CD;
UC

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2
Q
CD vs UC:
noncaseating granulomas = 
cobblestone mucosa = 
crypt abscess = 
pseudopolyps =
A

CD;
CD;
UC;
UC;

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3
Q

CD vs UC:
continuous involvment =
skip lesions =
always involves rectum =

A

UC;
CD;
UC

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4
Q
CD vs UC:
associated with p-anca = 
calcium oxalate kidney stones =
large increased risk of carcindoma = 
for both, name 2 skin conditions seen
A

UC;
CD;
UC
pyoderma gangreosum, erythema nodosum

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5
Q

CD vs UC:
string sign on barium swallow =
strictures =
loss of haustra –> ____ ____ on imaging =

A

CD;
CD;
lead pipe, UC

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6
Q

CD vs UC:
bloody diarrhea is esp associated with ______;
fistulas =
toxic megacolon =

A

UC;
CD;
UC

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7
Q

IBD:
notable arthritis that is associated =
bile problem =

A

ankylosing spondylitis;

primary sclerosing cholangitis

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8
Q

sulfasalazine is a combination of a ____ and _____;

activated by ____ and is used for both IBDs

A

sulfapyridine (anti-biotic);
5-aminosalicylic acid (anti-inflam);
colonic bacteria

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9
Q

what is target of infliximab and adalizumab?

A

soluble TNF alpha

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10
Q

6-mercaptopurine and cyclosporine are typically used for _____ (Rather than the other IBD)

A

UC

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11
Q

TNF alpha inhibitors need to be tested for ____ before starting therapy. there is also a potential risk of _____

A

Tb;

malignancy

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12
Q
Celicac:
intolerance of what pathogenic molecule?
associated with HLA\_\_ and \_\_\_;
\_\_\_\_ of villi;
crypt \_\_\_\_;
intraepithelail \_\_\_\_\_
A
gliadin;
DQ2, DQ8;
atrophy;
hyperplasia;
lymphocytosis
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13
Q

celiac:
usually affects _____ and ______;
associated with ____ deficiency;
anti-_____, anti ____, anti _____

A

distal duodenum, proximal jejunum;
IgA;
IgA anti-tissue transglutaminase, endomysial, deamidated gliadin

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14
Q

celiac:
what skin condition is associated with it?
increased risk of what cancer (high yield according to pathoma)

A

dermatitis herpetiformis;

T-cell lymphoma

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15
Q

most common small bowel malignancy:

A

adenocarcinoma

although these cancers are rare AF

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16
Q

carcinoid syndrome:
_____ positive;
increased ____ in urine

A

chromogramin;

5-HIAA

17
Q

hemorrhoids:
internal ones are _____ pectinate line and are ____;
external ones are ____ pectinate line and are _____

A

above, painless;

below, painful

18
Q

hemorrhoids:
internal ones are covered with _____ epithelium;
external are covered with _____;
_____ are associated with prolapsing

A

columnar;
squamous;
internal

19
Q

anal fissure:
____ the pectinate line;
usually located ____ due to ____ perfusion here

A

below (ie painful);

posteriorly, poor

20
Q

HPV:
causes _____ ______ (warts)
high risk types are serotypes ___ and ___
cause _____ _____ lesions/cancer

A

condyloma acuminata;
16, 18;
squamous intraepithelial

21
Q

cancer above pectinate line?

cancer below pectinate line?

A

adenocarcinoma;

squamous cell