Lecture 4 - Small Bowel/IBD/anorectal Flashcards
Crohn (CD) vs Ulcerative colitis (UC): any portion of GI, usually terminal \_\_\_\_\_: only colon: transmural inflam: only mucosal/submucosal:
CD (illeum);
UC;
CD;
UC
CD vs UC: noncaseating granulomas = cobblestone mucosa = crypt abscess = pseudopolyps =
CD;
CD;
UC;
UC;
CD vs UC:
continuous involvment =
skip lesions =
always involves rectum =
UC;
CD;
UC
CD vs UC: associated with p-anca = calcium oxalate kidney stones = large increased risk of carcindoma = for both, name 2 skin conditions seen
UC;
CD;
UC
pyoderma gangreosum, erythema nodosum
CD vs UC:
string sign on barium swallow =
strictures =
loss of haustra –> ____ ____ on imaging =
CD;
CD;
lead pipe, UC
CD vs UC:
bloody diarrhea is esp associated with ______;
fistulas =
toxic megacolon =
UC;
CD;
UC
IBD:
notable arthritis that is associated =
bile problem =
ankylosing spondylitis;
primary sclerosing cholangitis
sulfasalazine is a combination of a ____ and _____;
activated by ____ and is used for both IBDs
sulfapyridine (anti-biotic);
5-aminosalicylic acid (anti-inflam);
colonic bacteria
what is target of infliximab and adalizumab?
soluble TNF alpha
6-mercaptopurine and cyclosporine are typically used for _____ (Rather than the other IBD)
UC
TNF alpha inhibitors need to be tested for ____ before starting therapy. there is also a potential risk of _____
Tb;
malignancy
Celicac: intolerance of what pathogenic molecule? associated with HLA\_\_ and \_\_\_; \_\_\_\_ of villi; crypt \_\_\_\_; intraepithelail \_\_\_\_\_
gliadin; DQ2, DQ8; atrophy; hyperplasia; lymphocytosis
celiac:
usually affects _____ and ______;
associated with ____ deficiency;
anti-_____, anti ____, anti _____
distal duodenum, proximal jejunum;
IgA;
IgA anti-tissue transglutaminase, endomysial, deamidated gliadin
celiac:
what skin condition is associated with it?
increased risk of what cancer (high yield according to pathoma)
dermatitis herpetiformis;
T-cell lymphoma
most common small bowel malignancy:
adenocarcinoma
although these cancers are rare AF