Lecture 4 Preclinical

Question 1

dose response curve

Answer 1

dose concentration on x-axis and effet on y-axis. Low dose should have no effect and increasing the high dose should have no further effect

Question 2

Therapeutic Index (TI)

Answer 2

helps determine safety of drug
TI = TD50/ED50
dose causes toxicity in 50% of cases/dose produces therapeutic effect in 50% of pop dosed
larger number indictes a safer drug

Question 3

ADME

Answer 3

absorption, distribution, metabolism and excretion

Question 4

Bioavailability definition

Answer 4

amount of drug circulating in the blood that is available to act on targets

Question 5

steady state

Answer 5

desired blood drug level maintained over time

Question 6

physioloical antagonism

Answer 6

Drug B reduces the effect of Drug A

Question 7

Additive effect

Answer 7

Drug B adds to the effect of drug A

Question 8

Potentiation

Answer 8

Drug B does not cause an effect on its own but increases the effect of drug A

Question 9

Abuse/dependence liability

Answer 9

typially contain CNS acivity that produce euphora, hallucinations, or other mood changes
-must screen new drugs for abuse potential
-rats given known addictive drug such as cocaine then are presented with new drug, preferene for new drug indicates stronger abuse potential

Question 10

interoceptive properties

Answer 10

what the drug “feels “ like in the body
positive interoceptive effects means animal will work for the drug

Question 11

drug discrimination paradigm

Answer 11

right lever and left lever prouce food. when given saline only left lever produes food, when given reference drug on right lever produces food. For testing animal is given new drug to see if they press right or left lever