Lecture 1 Flashcards
DIN
Drug identification number, assigned by Health Canada to every drug product that has been on the market, located on label of prescription medication and over the counter drugs. Tells all pertinent information about a drug by looking up the DIN.
National Drug Code (US)
10 digit three segment form given by FDA for each approved drug, indicates manufacturer, formulation/dose/strength, and packaging
Chemical names of drugs
Conventional naming of drug based on its chemical structure
Generic drug name
Given to established drug and usually similar to chemical name. Follows conventions for drug type, I.e. suffixes. Before generic name companies can call drug by letters and numbers
Trade name of drug
Name of drug to be sold under patent, capitalized and most well known to public
Drug discovery definition
Process of finding a molecular candidate
Drug development definition
Tests performed on lead compound in vitro and in vivo and all preclinical studies for testing toxicology, pharmodynamics, and pharmacokinetics
Modern drug discovery and development pathway
Target identification, target validation, hit identifications, lead identification (hit to lead), lead optimization, candidate, preclinical development, clinical development, new drug approval
Rational approach
Three dimension knowledge of target structure involved in disease, drugs designed to intact with the structure, new field
Irrational approach
Empirical oberservations of effects of drugs from screening many chemical compounds, active component is isolated, it’s chemical structure is determined and modifications can be made.
patent definition
Right grnted by the government for any device, substance or method that is new, innovative and useful. Patents are valid for 20 yrs where the owner has all rights over the commercial returns
disease selection
based on populations affected, finanial return is critical, marketing critical
choosing drug target
drug target is structure involved in a disese pathway, ideally is disease specific, in modern times we understand the basic biology of disease before creating the drug, historically drugs were discovered before the target was known
hit identification
a molecule interats with a chosen target but not with other related targets in the body
hit-to-lead
molecule needs to be analyzed for chemical and metabolic stability, affinity for target, and drug-like properties
