Lecture 4 - epigenetics Flashcards
1
Q
What are agouti mice?
A
Mice who were fed with a different diet which resulted in a coat colour change in their offspring. Phenotypic not genotypic change
2
Q
When is the epigenetic profile first set?
A
At the gamete stage but is subject to change throughout development
3
Q
What are the epigenetic states of the developing embroy?
A
Mature gametes - high meth Zygote - high meth Embryo - low meth Developing fetus - increasing meth Fetal germ cells - low meth
4
Q
What is the danger of IVF?
A
Modifications to epigenetic environment that would usually occur do not as the epigenetic profile is set in a dish
5
Q
What does maternal-embryonic communication regulate?
A
- Features of blasto morphogenesis
- Coord of implantation
- maternal immunotolerance
6
Q
What is developmental plasticity?
A
‘Selecting’ the right phenotype to fit anticipated external environment
7
Q
True or false: Epigenetics play a role in non-communicable diseases
A
TRUE and they are rising
