Lecture 4 - Critical Care and the Role of the Pharmacist Flashcards

1
Q

Name the 4 different names for critical care

A

Critical care
ITU
ICU
HDU

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2
Q

Define level 0

A

Patients who’s needs can be met through normal ward care in an acute hospital

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3
Q

Define level 1

A

Patient at risk of deteriorating or those relocated from higher levels of care who’s needs can be met on an cute ward with additional advice and support from the critical care team

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4
Q

Define level 2

A

Patients requiring more detailed observation or intervention including support for a single failing organ system or post-operative care or those ‘stepping down’ from level 3 care

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5
Q

Define level 3

A

Patients requiring advanced respiratory support alone or basic respiratory support together with support of at least 2 organ systems. This includes all complex patients requiring support for multi-organ failure

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6
Q

Name some examples of people that come to critical care

A

Post-op
serious short-term condition e.g. cardiac arrest
serious infections e.g. pneumonia and sepsis
Shock - septic or circulatory
Trauma
Pancreatitis
Renal failure requiring renal replacement therapy (RRT)
Severe neurological conditions - Guilliain Barre

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7
Q

Name the types of non-invasive respiratory support

A

Nasal canula
Oxygen mask
Nasal High Flow (NHF)
CPAP

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8
Q

Name the types of invasive respiratory support

A

Endotracheal tube
Tracheostomy

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9
Q

What are the reasons for invasive respiratory support?

A

Protect the airway
Treat profound hyperaemia
post-operative - major surgery
progressive weakness of both the inspiratory and expiratory muscles
Rest exhausted patients - RR>30/min
Avoid or control hypercapnia

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10
Q

When is sedation used?

A

Alleviation of pain
Facilitation tolerance and reduce distress
endotracheal tubes
to augment the effectiveness treatment (some distressing settings)
Seizure control or management of intra-cranial pressure etc
Reduce anxiety and control agitation
During neuromuscular blockade

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11
Q

Reasons for analgesia use in critical care

A

Polytrauma
Post-op pain
Precipitating medical illness
Placement of drains
Prolonged immobility
Nursing care and therapy interventions
Endotracheal tube
Placement of lines

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12
Q

Give an example of a opioid anaesthetic

A

Alfentanil

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13
Q

Give an example of general anaesthetic

A

Propofol

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14
Q

What is the target mean arterial pressure (MAP)?

A

Probe inserted indirectly into the artery for a more accurate reading >65 (most patients), >80 (in CVD event

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15
Q

What happens if we do not address circulation?

A

If not addressed we the shock
Not getting enough oxygen going to where we need it
Deficiency of blood flow to the peripheral tissues of the body
Cellular hypoxia and metabolic acidosis

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16
Q

What can ICU delirium impact on?

A

Patients recovery
Increase morbidity
Mortality
Length of hospital stay

17
Q

Name the two types of delirium

A

Hyperactive delirium
Hypoactive delirium
Mixed - move between the two subjects

18
Q

Define hyperactive delirium

A

Really restless
Heightened arousal, restlessness, agitation, aggression

19
Q

Define hypoactive delirium

A

Sleepiness, lack of interest in daily activities, quiet and withdrawn

20
Q

Define CAM-ICU

A

Measures clarity of thought in ICU patients by measuring judgement and attentiveness

21
Q

What are the non-pharmacological treatments for delirium?

A

Optimising environmental factors
Reduce noise, reassure, and re-orientate
Provide glasses/ hearing aids
Music therapy
Encourage normal sleep by optimising light and disturbance
Consider melatonin

22
Q

Name the pharmacological treatments for delirium

A

Haloperidol, Clonidine, Quetiapine. Olanzapine

23
Q

Define hypernatraemia

A

Dehydrated/ sodium overload
- High levels of sodium

24
Q

Define hyponatraemia

A

Dilutional / SIADH
- Low levels of sodium

25
Why is AKI common in critically ill patients?
Impaired renal function Medication Primary renal disease
26
How is AKI/ risk of AKI managed?
Correcting circulation and optimising perfusion Avoid nephrotoxic medications May need RRT
27
Define CCVHD
Continuous venovenous haemodiafiltration Run 24/7 Flow rates lower
28
What are the indications for CVVHD?
Not based on SeCr/ eGFR Metabolic acidosis Hyperkalaemia Hypernatraemia Hyperphosphataemia Overdose/ poisoning Fluid overload Uraemia
29
What is given to reduce clot risk in patients on RRT?
Sodium citrate - citrate binds to calcium in blood inhibiting the clotting cascade, calcium is replaced into blood exiting the machine Heparin
30
What are the common types of fluids?
Colloids Vs crystalloids Sodium chloride 0.9% 'Balanced' fluids - Hartmanns, Plasmalyte
31
How is fluid balance managed?
Fluid restriction/ concentration preparation Pharmacological treatments - diuretics, RRT
32
When should parenteral nutrition be considered?
When there is inadequate nutrition for 4-7 days, should be considered pre-admission
33
What does parenteral nutrition composed of?
Water soluble and fat soluble vitamins, electrolytes
34
What is monitored on PN?
U and Es and LFTs
35
Why is enteral nutrition considered in critically ill patients?
Require a higher protein content in their nutrition for recovery
36
Define central venous catheter
Large vein higher flow rates larger blood volume
37
Define peripheral line
Standard IV therapy Limited conc and strengths due to risk of extravasation resulting in tissue damage/necrosis Limited lumens