Lecture 15 - Obesity Flashcards
Define obesity
Imbalance between calories consumed and energy expanded with metabolic parameters and appetite regulation via gastric and peripheral nervous systems
Define a underweight BMI
<18.5
Define a healthy weight BMI
18.5-24.9
Define a overweight BMI
Define baritatrics
Interventions used to manage patients with obesity
could be medical management - e..g surgical interventions
Define obesity I BMI
30-34.9
Certain interventions available on the NHS
What is the limitation of BMI?
Does not take into account patients muscle mass
Define obesity II BMI
35-39.9
Define obesity III BMI
40 or more
Name one of the main causes of obesity
Overeating
Define ghrelin hormone
primarily produced in the gastric fundus and is responsible for appetite stimulation
makes you feel hungry so encourages you to eat - less likely to be suppressed with patients who are obese
obesity - associated with reduced post-prandial ghrelin suppression
Define anorexigenic intestinal hormone
Includes GLP-1, peptide YY (PYY) and cholecystokinin (CCK)
Secreted in response to food intake, involved in digestion, insulin secretion and post-digestive metabolism and satiety
Obese patients - delayed, reduced or otherwise attenuated activity of anorexigenic hormone
(Body not telling you to stop eating)
Define leptin hormone
Predominately secreted by white adipose tissue
circulating levels correlate with fat mass and represent a hormonal signal of body energy stores
in individuals with more body fat, serum, plasma and CSF leptin levels are elevated
Sensitivity to leptin is reduced in people with obesity, reducing satiety despite high energy stores
Define liraglutide
Management of obesity
GLP-1 agonist
BMI of at least 35 and they have non-diabetic hyperglycaemia and a high risk of CVD based on risk factors such as HTN and dyslipidaemia
Prescribed in secondary care by a specialist multidisciplinary tier 3 weight management service
Has benefits on every meal on the day
Define the role of GLP-1
Gut hormone released into the circulation after meal ingestion which stimulates and inhibits glucagon release
Can suppress food intake and appetite and decelerate gastric emptying and induce satiety therefore reducing appetite and food intake
Attached acyl chain allows non-covalent bonding to albumin