Lecture 4: Cholera Flashcards
What toxin causes cholera?
The cholera toxin
How many cholera pandemics have there been?
7
Who initially discovered cholera?
Pacini
Who got initial recognition of the cholera causative agent?
Koch
Describe the features of v. cholerae?
Facultative anaerobic
Gram negative
Curved rod
What are the 2 serogroups of cholerae?
O1 and O139
What is v. cholerae associated with?
Zooplankton and shellfish
How does cholerae enter the human?
Ingestion
What does v. cholerae use to talk to other cells?
Quorem sensing
What genes for the cholera toxin are carried by what?
CTXphi
How long is cholera incubation period?
1-3 days
What are symptoms of cholera?
Mild diarrhoea
Mucus in faeces
Muscle cramps
What are 3 methods to cure cholera?
Chemotheraputic
Immunological
rehydration
What are 4 epidemic control measures of cholera?
Education Prevention of contaminated of water supplies Adequate supply of water Immunisation Good food hygiene
Why does Haiti have a high incidence of cholera?
Damage from earthquake
