Lecture 4 Flashcards
What are the three essential phases of healing?
Inflammatory, Proliferation(fibroblastic repair) and remodeling(maturation
How long is the inflammatory phase?
5 days
How long is the proliferation phase?
up to 21 days
How long is the remodeling phase?
up to one year
What should happen during the inflammatory phase?
stabalize and contain injured area
What should happen during the proliferation phase?
dispose of dead tissues and restores circulation
What should happen during the remodeling phase?
stabalize and reestablish the area
What is the immune response to an injury?
response to foreign body, release of antibodies and response is specific to antigen/invader
What is the inflammation response to an injury?
used to protect,used to localize, used to rid injurious agent and prepares for healing and repair
What is acute inflammation?
short onset and duration, change in hemodynamics, production of exudate and granular leukocytes
What is chronic inflammation?
long onset and duration, presence of non-granular leukocytes and extensive scar tissue
What are 5 signs of inflammation?
redness, swelling/edema, pain, heat and loss o function
What is the purpose of inflammation?
Protect, localize, decrease injurious agents and prepare for healing and repair
How can you control swelling?
R.I.C.E
What does R.I.C.E.S stand for?
Rest, ice, compression and Elevate and stabalization
Why do we use ice?
to reduce the risk the secondary hypoxic injury,
cold=less metabolism=less need for oxygen=less hypoxic damage
Why does cold decrease the need for oxygen and nutrients?
slower metabolism
what is margination?
neutrophils and macrophages line up against cell wall
What are phagocytes?
neutrophyls, macrocytes and leukocytes that ingest micro-organisms, damaged cells and/or foreign particals
What is Diapedesis?
movement of WBC out of small arterial vessels
What is Exudate?
accumulation of fluid that penetrates cell wall into extravascular space
What is Vasoconstriction?
decrease in diamete of blood vessels
What are the 8 phases of inflammation?
Injury Ultrastructural changes Metabolic (hypoxic) changes Activation of chemical mediators Hemodynamic changes Permeability changes Leukocyte migration Phagocytosis
In what hour of the Inflammatory response phase does the following happen: Vasoconstriction and coagulation occur to seal blood vessels and chemical mediators are released
Immediately followed by vasodilation of blood vessel
First hour