Lecture 4 Flashcards
1
Q
Attachment factors
A
GAGS (glycosaminoglycans). - charged. bind viruses via electrostatic interactions
2
Q
HRV Receptors
A
NON ENVELOPED
Major group: ICAM-1
-intracellular adhesion
Minor Group: LDLR
-lipid uptake
3
Q
HIV Receptors
A
Primary: CD4
Secondary: chemokine receptors
CCR5/V3/CxCR4(AIDS)
4
Q
Influenza A glycoproteins
A
HA
NA
*Sialic acid linkage determines host range
5
Q
COVID glycoproteins
A
Spiked (S)
Cleaved into S1 and S2
S1 contains receptor binding domain
6
Q
COVID receptors
A
primary receptor: ACE-2
cleaves angiotensin (inflammation/blood pressure)
secondary receptor: TMPRSS2
serine protease
cleaves S into S1 and S2
*glycoprotein fusion peptide in S2
7
Q
VIrus entry:
A
Attachement, penetration, uncoating
8
Q
virus penetration:
A
required to deliver genome to cytoplasm
