Lecture 2

Question 1

Virus Definition

Answer 1

nucleic acid surrounded by a protein coat. either RNA or DNA

Question 2

RNA single strand, positive, enveloped viruses

Answer 2

Togaviridae: alphavirus, rubella
Flaviviridae: yellow fever, hepatitis C, west nile
Coronaviridae: SARS
Retroviridae: HIV

Question 3

RNA single strand, positive, non-enveloped

Answer 3

Picornaviridae: common cold, polio, FMDV, Hepatitis A
Callciviridae: gastroenteritis

Question 4

RNA single strand, negative, enveloped

Answer 4

Filoviridae: ebola/marburg
Rhabdoviridae: rabies
Bunyaviridae: hantavirus syndrome
Orthomyxoviridae: influenza
Paramyxoviridae: mumps/measles
Arenaviridae: Lassa fever

Question 5

RNA double strand, non-enveloped

Answer 5

Reoviridae: gastroenteritis

Question 6

RNA Viruses facts:

Answer 6

smaller genomes (3-32), mostly singel stranded, + or -

Question 7

Positive sense RNA virus genomes

Answer 7

can be directly translated into viral proteins
Often have 5’cap and 3’poly A tail

Question 8

Internal ribosome entry sites

Answer 8

common in + sense RNA viruses. found in noncoding region

Question 9

Negative Sense RNA viruses:

Answer 9

genome is reverse complements of the coding strand. NO CAP OR POLY A TAIL

Question 10

non-segmented negative RNA viruses

Answer 10

Filo, paramyx, Rhabdo

Question 11

segmented negative RNA viruses

Answer 11

orthomyx, bunya

Question 12

DNA viruses facts:

Answer 12

either have small (5) or large genomes(1.2) mainly double strand.
often spliced and contain overlapping genes

Question 13

Linear DNA viruses

Answer 13

herpes, pox, adeno

Question 14

circular DNA viruses

Answer 14

hepatitis, papillo, parvo