lecture 4

Question 1

antagonist

Answer 1

no intrinsic activity (when bound to receptor, nothing happens), inhibitor

Question 2

agonist

Answer 2

intrinsic activity, activator, receptor affinity

Question 3

partial agonist

Answer 3

blocks other agonists

Question 4

ACh

Answer 4

causes reduction in blood pressure

Question 5

competitive antagonism

Answer 5

more of sort wins, antagonist reduces potency of agonist without affecting the agonist efficacy, curve moves to the right because the concentration increases.

Question 6

noncompetitive antagonism

Answer 6

antagonist reduces the efficacy of an agonist, changes the maximum and curve moves a bit to the right.

Question 7

functional antagonism

Answer 7

have a function, two agonist induce an opposite effect via activation of different receptors

Question 8

B1

Answer 8

stimulates heart rate

Question 9

M3, B2

Answer 9

Lung

Question 10

M2, B1

Answer 10

Heart

Question 11

GPCR’s activate their effect system via…

Answer 11

Ga and Gby subunits

Question 12

Gi

Answer 12

inhibits

Question 13

Gs

Answer 13

stimulates

Question 14

Forskolin

Answer 14

direct stimulation of AC without receptor activation

Question 15

Theophylline

Answer 15

inhibition of cAMP-specific phosphodiesterase

Question 16

PCLS

Answer 16

longplakjes

Question 17

vasodilators

Answer 17

NOS, EDRF

Question 18

main effect of insulin

Answer 18

Reduction of glucose transporters at the cell membrane