Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Med Chem Midterm > Lecture 4 > Flashcards

Lecture 4 Flashcards

You may prefer our related Brainscape-certified flashcards:
Periodic Table flashcards Chemistry 101 flashcards AP® Chemistry flashcards Organic Chemistry 101 flashcards
1
Q

Most drugs belonging to the same pharmacologic class have……

A

certain structural features in common.
for example:

-a basic Nitrogen
-an aromatic ring
-an ester or amide group
-a hydroxyl group (phenolic or alcoholic)
-an aliphatic or alicyclic portion of the molecule

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

similar structural features of molecules permit what?

A

these functional groups to be oriented in a similar pattern in space

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

functional groups are important in _____ interactions.
different arrangements of functional groups allow for…..

A

functional groups are important in BINDING SITE interactions.

different arrangements allow for HIGHLY SPECIFIC binding

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what are the structural requirements for narcotic analgesic activity?

A

-a basic nitrogen
-an aromatic ring
-a tetrasubstituted carbon
-a 2 carbon chain linking the tetrasubstituted carbon and the basic N

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

name 3 narcotic analgesics.
when something has “narcotic analgesic activity” that means it affects…..

A

morphine
methadone
meperidine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

not only are similar structures important, but also their…..

A

ARRANGEMENT (ie: a 2 carbon chain linking the tetrasubstituted carbon to the basic N in narcotic analgesics)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

true or false

methadone and meperidine possess the same pharmacological activity as morphine

A

TRUE – even though they look very different

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

morphine, methadone, and meperidine all produce their effects by…..

A

binding to opioid receptors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

who is the “father of med chem”

what did he say

A

Paul Ehrlich
he coined the term “receptors” to explain structural similarities in molecules with similar biological activity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

meperidine and methadone are ___ ___

A

synthetic analgesics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

endogenous opioid agonists

A

endorphins and enkephalins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

true or false

the naturally produced opioid agonists (endorphins and enkephalins) produce the same effect as opioids, but through a different mechanism

A

FALSE – they all produce their effect by binding to opioid receptors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

broadly speaking, the term “receptor” refers to…..

A

a relatively SMALL region of a macromolecule which may be:

-an isolatable enzyme
-a structural and functional component of a cell membrane or
-a specific intracellular substance such as a protein or a nucleic acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

receptors, most of the time, are ____ molecules

A

PROTEIN

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Explain how receptors are visualized and how a biological response is produced when interacting with a drug

A

specific regions of these macromolecules (receptors) are visualized as being oriented in space in such a way that permits their functional groups to interact with COMPLEMENTARY FUNCTIONAL GROUPS OF THE DRUG

this interaction initiates a CHANGE IN THE STRUCTURE AND FUNCTION OF THE RECEPTOR (macromolecule) THAT ULTIMATELY LEADS TO AN OBSERVABLE BIOLOGICAL RESPONSE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Most drugs produce their effects by a ______ mechanism

A

receptor mediated

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

as mentioned, most drugs produce their effects through a receptor mediated mechanism.

are their any exceptions to this?

A

YES, there are 3 exceptions

  1. general anesthetics
  2. osmotic diuretics
  3. antacids
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

explain how osmotic diuretics do NOT produce their effects via a receptor mediated mechanism

A

they simply produce an osmotic gradient in the renal tubules, promoting the elimination of water in the urine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

explain how antacids do not produce their effects through a receptor mediated mechanism

A

through an acid-base neutralization of the hydrochloric acid found in the stomach

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

do antacids require absorption to produce their effects?

A

NO

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

explain how general anesthetics do not produce their effects via a receptor-mediated mechanism

A

it is a general signal – not through a receptor

22
Q

true or false

in drug design, the goal is to design drugs that are selective as possible to their receptors

A

TRUE – this will limit side effects

this is bc there are a variety of receptors with similar structural requirements for their ligands in multiple organs and tissues throughout the body. Receptors for the same ligand are found in multiple tissues

23
Q

true or false

the role of a medicinal chemist is to design drugs that will bind selectively to the desired receptors with low affinity, so that side effects will be minimal

A

FALSE – HIGH AFFINITY

24
Q

Give a specific example that demonstrates the need for high specificity drug-receptor interactions

A

there is a new class of cancer drugs called protein kinase inhibitors.

protein kinases are everywhere throughout the body, so the drug has to be VERY SPECIFIC to its target in order to receive the desired effects, and not side effects and/or toxicity

25
Q

_______ of drugs influence their ability to reach the site of action AND their interaction with the receptors AFTER reaching the site of action

A

STRUCTURAL FEATURES

26
Q

what does steric mean

A

the arrangement of atoms in space

27
Q

what are the steric factors which influence drug activity?
(ie: ability to reach site of action, interaction with receptors after reaching the site of action)

A
  1. Isosterism
  2. Optical isomerism
  3. geometric isomerism
  4. conformational isomerism
28
Q

isosterism, optical isomerism, geometric isomerism, and conformational isomerism all affect what?

A

the orientation of the drugs in space that affect drug-receptor interaction

29
Q

explain the term “isostere”

A

refers to the groups of atoms that impart similar chemical or physical properties to a drug molecule DUE TO SIMILARITIES IN SIZE, ELECTRONEGATIVITY, OR STEREOCHEMISTRY

30
Q

The ____, ____, and ____ characteristics of isosteric atoms or groups of atoms makes them…….

what is this called?

A

the steric, electronic, and solubility characteristics of isosteric atoms makes them INTERCHANGEABLE IN DRUGS OF THE SAME PHARMACOLOGICAL CLASS

this is the phenomenon of isosterism, or bioisosterism (when applied to med chem)

31
Q

define isosterism

A

isostere = groups of atoms that impart similar chemical or physical properties to a drug molecule due to similar size, electronegativty, or stereochemistry

the steric, electronic, and solubility characteristics of these isosteres makes them INTERCHANGEABLE in drugs of the same pharmalogical class

this is known as isosterism

32
Q

give a typical example of isosterism

A

“isoelectric” – same # of electrons

33
Q

true or false

when replacing 1 functional group with another on the basis of isosterism (similar charge, size, electronegativity, etc) ALL PROPERTIES MUST BE SIMILAR between the new and old functional groups

A

false – can be just 1 similar quality, can be multiple. all depends on what quality of the original molecule that you want to maintain

34
Q

give some examples of what qualities of drugs you would want to modify, on the basis of bioisosterism

A

-improve binding potency and/or induce side effects
-improve the duration of action
-give metabolic/chemical stability

35
Q

what are the 2 classifications of bioisosteres?
differentiate them

A

classical and nonclassical

classical = earlier. monovalent/divalent/trivalent/tetrasubstituted and ring equivalents

nonclassical = later
exchangeable groups (ie: carbonyl and sulfonyl) and cyclic vs noncyclic structures

36
Q

give examples of monovalents that are interchangeable, according to the classical bioisosteres theory.

they are interchangeable on the basis of ____ similarity

A

SIZE SIMILARITY

halogens (more so Cl and Br, F is too small)
-X (represents halogen)
-CH3
-NH2
-OH
-SH

37
Q

thioether functional group

A

R-S-R

38
Q

give examples of divalent atoms that are interchangeable, on the basis of classical isosterism

A

R-O-R’ (ether)
R-S-R’(thioether)
R-NH-R (amine)
R-CH2-R

39
Q

give examples of trivalent classical bioisosteres

A

R-N double bond R’
R-CH double bond R’

40
Q

give examples of tetrasubstituted classical bioisoteres

A

C with double bond R on both sides
N+ with double bond R on both sides

41
Q

true or false

when swapping functional groups on the basis of bioisoterism, the addition of a full - or full + charge could be a good thing or bad thing, depending on the desired effects of the drug. the important thing is that we are able to back up the swap with scientific rationale

A

TRUE – can be good or bad

42
Q

what is a good isostere of benzene?

A

thiophene, furan, pyridine

43
Q

explain the rationale of why benzene can be replaced by thiophene

A

even though thiophene has 1 less carbon then benzene, it can still be substituted because S has a higher lipophilicity than C, so the lipophilicity of the molecule is still relatively the same even though there is 1 less carbon

44
Q

benzene can be replaced with pyridine. explain why this can potentially pose an issue

A

the electronegativity is slightly different, being that in pyridine, the electrons are unevenly distributed (more polar) than in benzene

45
Q

under classical isosteres, methyl can be replaced with chlorine.
what is an important consideration with this?

A

SIZE is being maintained, but NOT electronegativity

46
Q

with the intent of maintaining both size AND electronegativity, what can Cl be replaced with?

if only size were a concern, what could it be replaced with?

A

to maintain both size and electronegativity, replace Cl with CF3

to maintain just size, replace with methyl

47
Q

carbonyl and sulfonyl are nonclassical bioisosteres

what is an important consideration when replacing one with the other?

A

the 2 are NOT isoelectric, but may have a similar polarity

48
Q

true or false

carboxylic acid and sulfonic acid have similar electronegativity

A

true

49
Q

a nonclassical bioisostere of amides is _______

why is this useful?

A

sulfonamides

amides are easily hydrolyzed in the GI tract. Replacing amide with sulfonamide can prevent premature hydrolysis in the GI tract.

this is used in peptide drugs which have an issue with metabolic instability. peptide drugs are made of amino acids and there are many proteases in the GI tract. the drug may not survive.

thus, the least destructible way of resolving this is by replacing with a sulfonamide which is NOT HYDROLYZED BY PROTEASES.
but, it must be considered – will this negatively affect drug activity?

50
Q

the nonclassical bioisostere of carboxylic acid is sulfonic acid.

what is an important consideration?

A

sulfonic acid is much more acidic.
the 2 may have similar electronegativities, but acidity difference may pose an issue

51
Q

NONCLASSICAL bioisosteres are replacements of….

A

functional groups

52
Q
A

Med Chem Midterm (11 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions