Lecture 4

Question 1

High throughput means

Answer 1

Low complexity

Question 2

What is a limitation of primary human hepatocytes

Answer 2

limited life span in culture
donor variability
not high throughput

Question 3

what is a limitation of precision cut liver slices

Answer 3

damage response

Question 4

what is toxcast

Answer 4

automated screening technologies with a lot of assays

Question 5

formula for risk assessment

Answer 5

hazard(identification+characterization)xexposure

Question 6

Aim of hazard characterization

Answer 6

to identify a dose without appreciable adverse health effects in the test systems under the experimental conditions

Question 7

What is the benchmark dose

Answer 7

model-based, interpolated dose that produces a level of response defined by the BMR

Question 8

What is the benchmark response

Answer 8

predefined level of response in a population that is considered to either be adverse or represent significant change

Question 9

In silico methods contribute to

Answer 9

hazard identification
internal exposure estiamte