Lecture 4 Flashcards

1
Q

Describe the general features of muscle tissue

A
  • elongated cells celled muscle cells/fibres or myocytes
  • cells use ATP to generate force
  • contraction allows for movements, posture, and heat
  • muscle makes up 50% of the body tissue mass
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2
Q

What are the types of muscle

A

Skeletal
Cardiac
Smooth

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3
Q

Describe Skeletal muscle

A
  • Roughly 650 skeletal muscle
  • Attached to bones via tendons
  • Long, cylindrical cells
  • Appear striated
  • Multinucleated (many peripheral nuclei pushed to the side)
  • Contraction under conscious control
  • Functions for motion, posture, heat, protection

Smallest: stapedius
Longest: Sartorius

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4
Q

Describe the stapedius

A

The smallest skeletal muscle - 1.25mm - in the body. Located in ear
Functions to modify intensity of sound by tensing bones
Important because some sounds could shake bones apart - e.g. while crunching
When you have Bell’s Palsy and facial nerve paralysed, the muscle doesn’t work due to nerves and therefore sounds are loud

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5
Q

Describe the Sartorius

A

The largest skeletal muscle - 60cm.
Cells are long as run the whole length
Involved when you externally rotate your hip e.g. when trying to look under your foot/shoe

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6
Q

What causes striations of muscle fibres

A

Highly organised arrangement of myofibrils within the cells

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7
Q

What are myofibrils

A

They more or less fill the cytoplasm (sarcoplasm) of the muscle fibre and extend its entire length within the cell

Composed of thin and thick filaments (myofilaments)

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8
Q

What are myofilaments

A

Filaments within the myofibrils
They do not extend the length of the muscle fibre, but arranged in sarcomeres

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9
Q

What are thin filaments made from

A

Mostly actin

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10
Q

What are thick filaments made form

A

Myosin

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11
Q

What is the sacromere

A

The basic functional unit of the myofibril

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12
Q

Where is the Epimysium

A

Fascia that surrounds the anatomical muscle

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13
Q

Where is the Perimysium

A

Around the fascicles (surrounds multiple collections of muscle fibres/cells)

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14
Q

What are fascicles

A

Groups of muscle cells

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15
Q

Where is the endomysium

A

Around collections of muscle fibres/cells

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16
Q

What is the sarcolemma

A

The actual cell
plasma membrane

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17
Q

What is the sarcoplasm

A

Muscle cell cytoplasm

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18
Q

What is the A band

A

The dark, middle part; contains all the thick filaments

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19
Q

What is the I band

A

The thin filaments, but no thick filaments

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20
Q

What is the H zone

A

The thick filaments, but no thin filaments

21
Q

What is the M line

A

The middle of sarcomere (holds thick filaments together)

22
Q

What are the Z discs

A

They pass through centre of I band (between sarcomeres) made up of
“actinins” – that link filaments of adjacent sarcomeres

23
Q

Describe Cardiac muscle

A

Striated
Branched
Single central nucleus
Involuntary contraction
Fibres join end-to-end through intercalated discs

24
Q

What do intercalated discs contain

A

Desmosomes - adhesion/binding in contraction
Gap junctions - communication, co-ordinated and rapid conduction

25
Describe smooth muscle
Short, small, spindle shaped Involuntary contraction Non-striated (smooth) - but still have thin and thick filaments that attach to dense bodies Single central nucleus Located in the walls of hollow internal structures (blood vessels, intestines, skin)
26
What are dense bodies made from
A major protein is actinin
27
Name the three main functions of the nervous system
Sensory: detection of internal and external stimuli and transfer to CNS Integrative: analysis and storing of information Motor: stimulation of effectors (e.g. muscle and glands) through PNS i.e. motor here means “effector”
28
What are the two types of cells in the nervous system
Neurons Neuroglia
29
What are neurons
Have a cell body Have branched dendrites Have axons Longest cells in the body (up to 1m - spinal cord to toe) Functions;: Conscious and unconscious control For our purposes: Do not divide High metabolic rate (die rapidly without O2)
30
What are dendrites
They receive/input nerve impulses (action potentials) into the cell body
31
What are axons
Outer portion of neutron Carries the nerve impulse away from the neuron
32
Name the four types of neurons
Unipolar Bipolar Multipolar Anaxonic
33
Describe multipolar neurons
Have 2 or more dendrites Single axon Most common neurons in CNS All motor neurons are multipolar Some of the longest (spinal chord to toe muscles)
34
Describe Bipolar neurons
1 dendritic process (can branch at tip but not at cell body) 1 axon Has cell body between axon and dendrite Rare and small Location: Special sense organs (sight, smell, hearing) relay information from receptor to neurons
35
Describe unipolar neurons
The dendrites and axon are continuous Cell body off to one side Whole part from where dendrites converge (come together into 1) is called the axon Most sensory nerves are unipolar Very long (1m) like motor nerves CNS-toe tip.
36
Describe anaxonic neuron
Rare and function poorly understood Anatomy cannot distinguish dendrites from axons Found in brain and special sense organs
37
Describe neuroglia
Smaller than neurons but more numerous Found in both CNS and PNS Make up ~50% the volume of the CNS (“glue”). Do not propagate action potentials, but can communicate. Can divide within the mature nervous system Functions: Physical structure of nervous tissue Repair framework of nervous tissue Undertake phagocytosis Nutrient supply to Neurons Regulate interstitial fluid in neural tissue.
38
What are astrocytes
Star-shaped; largest; most numerous of neuroglia. Syncytium network. Support (have microfilaments) and repair (scar). Communicate with neurons via 'gliotransmitters’ e.g. glutamate Maintain environment around neuron e.g. by regulating ions. Maintain blood-brain barrier via endothelium. Wrap around vessels and influence their permeability
39
What are oligodendrocytes
Form insulating multilayered myelin sheath (protein lipid layer) around CNS axons. Can myelinate more than one neuron cell’s axon. Accelerate the action potential.
40
What are microglia
They are phagocytic (resident macrophages) - protection Can be inactive or active
41
What are Ependymal cells
Produce cerebrospinal fluid (CSF). Line the Cerebrospinal Fluid (CSF)-filled ventricles in the brain and the central canal of the spinal cord. These single layer of predominantly cuboidal cells have cilia (flow) and microvilli (sampling). Located in ventricles and in other locations where CSF found. CSF mechanical buffer; moves nutrients and waste
42
What are the two different types of neuroglia
CNS neuroglia PNS neuroglia
43
Name the CNS neuroglia
Astrocytes Oligodendrocytes Microglia Ependymal cells
44
Name the PNS neuroglia
Schwann cells Satellite cells
45
Describe schwann cells
"PNS version of CNS oligodendrocyte” Form insulating myelin sheath around axons or can just support and surround several non-myelinated axons. (Note: One Schwann cell per axon for myelination but more axons/cell if just support).
46
Describe the Satellite cells
They surround neuron cell bodies. Support and fluid exchange (equiv. to astrocytes in CNS).
47
What are the axon terminals
The branch like things that come out of axons
48
What are dendritic branches
The things that come together to form a dendrite