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MicroB test 3 > Lecture 36 > Flashcards

Lecture 36 Flashcards

1
Q

Besides from rats, where else can S. moniliformis come from?

A

Transients in animals that feed on rodents (e.g., dogs, cats) -Turkeys -Contaminated water and milk (from rat feces)

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2
Q

Cause of Ulceroglandular tularemia and Symptoms?

A

From rabbits and ticks (Rabbit-associated disease)Enters via scratch or abrasion, spreads lymphatically

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3
Q

Characteristic of Francisella tularensis

A

Aerobic Gram-negative rod Facultatively intracellular (in macrophages)

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4
Q

Clinical disease from Capnocytophaga canimorsus

A

Cellulitis, Gangrene, arthritis, endocarditis

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5
Q

Clinical symptoms from B. henselae

A

Remember that it is dived into typical (usually benign) and atypical symptomsTypical: characterized by chronic swollen lymph nodes. Often self-limiting Atypical: altered mental state, confusion, vision loss, prolonged fever, arthritis, atypical pneumonia, abdominal pain

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6
Q

Clinical symptoms from Pasteurella multocida

A

Local wound infection from cat bites that rapidly progresses into cellulitis

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7
Q

Clinical symptoms of Brucella

A

Acute disease; flu-like symptoms, depression, anorexia, and Profuse sweating Chronic disease: meningitis, endocarditis, suppurative joint infections, renal damage

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8
Q

Describe Bubonic plague (fleas)

A

Bacteria multiply in lymph nodes and turns into buboes form (inflamed, necrotic, hemorrhage)

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9
Q

Describe Capnocytophaga canimorsus

A

Gram negative rod

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10
Q

Describe Pneumonic plague

A

From inhalation of Y. pestis -Hemorrhagiv pneumonia -90% (High) mortality

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11
Q

Describe Streptobacillus moniliformis

A

Long, thin, gram-negative rod paste-11489037516803.jpg

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12
Q

Describe the four patterns of Bacillary Angiomatosis

A
  1. Globular papules or nodules 2. Violaceous nodules (resembles Kaposi sarcoma) 3. Lichenoid violaceous plaque 4. Subcutaneous nodule with or without ulceration
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13
Q

Describes Septicemic plague

A

“Black Death”Subcutaneous hemorrhages DIC, Vascular collapse, necrotic

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14
Q

Diagnosis for B. henselae

A
  1. Lymph Node biopsy: Warthin starry silver stain paste-9191230013443.jpg 2. Serological tests or PCR
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15
Q

Diagnosis method for Pasteurella multocida. Growth and stain.

A

Gram negative coccobacillus with Bi-polar staining Growth on blood and chocolate agar

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16
Q

Diagnosis of Brucella

A
  1. History is most important 2. Serology 3. Gram stain 4. Blood culture
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17
Q

Diagnosis of Francisella

A

Serology Sputum stain: Gram stain negative Growth: BCYE agar (similar to legionella)

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18
Q

Dog bite septicemia, cellulitis is from what bacteria?

A

Capnocytophaga canimorsus

19
Q

Erysipelothrix rhusiopathiae: Clinical Disease What does it cause? Symptoms:

A
  1. Erysipeloid Symptoms: Inflammatory skin lesion at site of trauma after 2-7 days with decoloration (into purple) Lesion is painful and pruritic 2. Septicemic (uncommon) Associated with acute onset endocarditis
20
Q

Four Zoonoses that transmit disease by bite/scratch

A

Pasteurella multocida Bartonella henselae Capnocytophaga canimorsus Streptobacillus moniliformis

21
Q

Francisella tularensis causes

A

Tularemia (aka Rabbit Fever)

22
Q

How are Brucella transmitted?

A
  1. Direct contact with infected animal 2. Contaminated food products (ex. unpasteurized milk) 3. Inhalation of aerosols
23
Q

Infection from Bartonella henselae is mostly from?

A

Exposure to cats: Scratches, bites, and possibly from cat fleas Causes cat-scratch disease (usually benign)

24
Q

Micorscopy and culture for Erysipelothrix rhusiopathiae

A

Non-motile, catalase-negative, alpha-hemolytic on BA. Produces H2S on triple sugar iron agar (TSI)

25
Q

Mode of transmission and symptoms associated with transmission

A

Entry through skin: Ulceroglandular tularemia - Have to have a cut or wound (usually seen in hands) - Local lymphadenopathy Inhalation: Pulmonic tularemia Ingestion: Oropharyngeal tularemia

26
Q

Name and describe the two forms of diseas from S. moniliformis

A
  1. Rat-bite fever (2-10 day incubation with abrupt onset of flu-like symptoms) - Maculopapular rash few days later with recurrent epsidoes of headache and arthralgia. Can develop Carditis, meningitis, and pneumonia in untreated patient 2. Haverhill fever - Consumption of contaminated food or water. Cause vomiting and pharyngitis
27
Q

Name the four pathogens of Brucella spp. and what animal is it associated with each pathogen

A

B. abortus (cattle) B. meletensis (goats and sheep) B. suis (pigs) B. canis (dogs)

28
Q

Natural flora for Erysipelothrix rhusiopathiae

A

In GI tract of animals espcially in pigs

29
Q

Only Zoonoses with Gram positive? What shape is it?

A

Erysipelothrix rhusiopathiae Shape: Microaerophilic rods or filaments

30
Q

Origin of Bacillary Angiomatosis

A

Caused by B. henselae and B. quintana

31
Q

Pasteurella multocida characteristics: Stain? Shape Biochemical reactions?

A

Gram-negative coccobacillus, oxidase-positive

32
Q

Rat-bite fever is associated with what bateria?

A

Streptobacillus moniliformis

33
Q

State the different Yop Genes

A

YopH: dephosphorylates proteins required for phagocytosis YopE: induces cytotoxicity by disrupting actin filaments YopJ/P: initiates apoptosis in macrophages

34
Q

Three Zoonoses that transmit disease through contact with infected animals

A

Erysipelothrix rhusiopathiae Brucella spp. Francisella tularensis

35
Q

Transmission by Bacterial Zoonoses

A

Direct or indirectly from animals 1. Biting insects (vector-borne diseases 2. Inhalation of airborne contaminated secretions 3. Ingestion of contaminated food or drinks 4. Xenotransplantation

36
Q

Transmission from Pasteurella multocida is most likely by?

A

Cat/dog scratch/bites (most likely from cat bites)

37
Q

Virulence factors of Y. Pestis Describe

A
  1. Fraction 1 (F1) gene: Antiphagocytic protein capsule 2. Plasminogen activator (Pla) protease gene: Degrades complement components C3b and C5a (no opsonization and chemotaxis) Degrades fibrin clots, allows rapid spread of bacteria 3. Yop genes: Type III secretion system (allows resistance of phagocytic killing)
38
Q

What are the three forms of Y. Pestis?

A
  1. Bubonic plague (fleas) 2. Septicemic plague - “Black death” 3. Pneumonic plague (inhalation)
39
Q

What does Brucella cause in animals?

A

Aborted Fetuses paste-12889196855299.jpg

40
Q

Who is at highest risk for Bacterial Zoonoses?

A

Occupational hazard: Farmers, Vets and Pet owners

41
Q

Y. pestis: diagnosis

A

Gram stain of Lymph Node Aspirate - Bipolar staining - Dangerous to culture Fluorescent antibody tests

42
Q

Yersinia Pestis Causes? Characteristics? Common location and carrier?

A

Causes? Plague Charactericts? Oxidase negative, gram negative rod, urease negative, lactose negative, indole negative Found in desert southwest especially in prairie dogs

43
Q

Zoonoses with vector-borne transmission

A

Yersinia Pestis

MicroB test 3 (5 decks)

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