LECTURE 35 - HORMONES 4 Flashcards
how does signal amplification happen
through second messengers
when enzymes activate enzymes, the number of affected molecules increases geometrically in a cascade
summary of how GPCRs work
how does ghrelin work
once ghrelin is overstimulated it internalises
works in the NPY/AgRP neuron
what are the challenges to developing an inhibitor to ghrelin
ghrelin has pleiotropic effects: involved in things other than appetite, cannot play around with it too much
what kind of receptor is the leptin receptor
what is parabiosis?
the anatomical joining of two individuals, especially artificially in physiological research
what are the defects in ob/ob and db/db mice?
ob/ob: do not produce leptin
db/db: produce leptin but don’t have the receptor for it
both types of mice are fat
what are the outcomes of the combinations of db/db + wt mice, db/db+ob/ob, and ob/ob+wt
mechanisms of leptin
how does the leptin receptor work
