Lecture 35-38

Question 1

Lipolysis is the process of cleaving the bond between a fatty acid and glycerol backbone from a triglyceride molecule. True or false?

Answer 1

True

Question 2

Insulin increases phosphodiesterase activity in adipocytes. What effect does this have on lipolysis?

Answer 2

It will inhibit lipolysis. PDE breaks down cAMP which will activate PKA and PKA will activate hormone sensitive lipase which is the enzyme responsible for lipolysis.

Question 3

What is the enzyme responsible for lipolysis?

Answer 3

hormone sensitive lipase

Question 4

Tolbutamine and glyburide can inhibit carnitine palmitoyltransferase 1 which leads to muscle weakness, pain, and exercise intolerance. Why do these drugs cause exercise intolerance?

Answer 4

They inhibit use of fats as a fuel source

Question 5

Metformin decreases the activity of glucose-6-phosphatase. What effect will this have on the body?

Answer 5

It will inhibit gluconeogenesis in the liver & inhibit glycogenolysis in the liver.

Question 6

Why do blood glucose levels not drop much overnight?

Answer 6

Glycogenolysis and gluconeogenesis in the liver provides glucose to dump into the blood