Lecture 34: Invertebrate models of brain disease

Question 1

Krasavietz

Drunk Fly - Alcoholism Model

Lecture 34

Answer 1

Uninterested in alcohol, becomes too sedated, skips the “fun” stimulating effects

Question 2

Cheapdate

Drunk Fly - Alcoholism Model

Lecture 34

Answer 2

Increased sensitivty to alcohol

Question 3

Happyhour

Drunk Fly - Alcoholism Model

Lecture 34

Answer 3

Less sensitive to sedative effects, but normal sensitivity to stimulating effects
Higher risk of alcoholism

Question 4

Hangover

Drunk Fly - Alcoholism Model

Lecture 34

Answer 4

Don’t develop tolerance to alcohol
Lower risk of alcoholism

Question 5

Advantages of drosophilia?

Lecture 34

Answer 5

• Rapid life cycle
• Sexually dimorphic
• No IACUC approval needed
• Can insert pretty much any gene

Question 6

Advantages of C. elegans?

Lecture 34

Answer 6

• Transparent (visible aging)
• Cheap handling (ability to keep frozen)
• Hard to kill
• No IACUC approval needed