Disease Pathologies

Question 1

Stroke

Question 2

Alzheimer’s Disease

Alive vs. Postmortem

Answer 2

Alive:
* enlarged ventricals
* cortical shrinkage/reduced gray matter

Postmortem:
* AB-amyloid plaques
* neurofibriliary tangles

Question 3

Parkington’s Disease

Answer 3

• Symptoms: Inability to initiate movement
• Anatonomical abnormalities: Degeneration of dopaminergic substantia nigra inputs to thalamus

Question 4

Huntington’s Disease

Symptoms & Anatonomical Abnormalities

Answer 4

• Symptoms: Excessive inappropriate movement, hyperkinesia, dementia
• Anatonomical abnormalities: degeneration of caudate, globus pallidus, or putamen -> lack of inhibition to thalamus

Question 5

Epilepsy

Diagnostic criteria (2) & treatment

Answer 5

1. Reccurent seizures (2+) (not caused by electrolyte imbalance or alcohol withdrawal)
2. Abnormal EEG

Question 6

TBI

Question 7

Coma

Question 8

Ataxia