Lecture 305: regulation Flashcards
1
Q
ATP activates/ deactivates
A
- activates = gluconeogenesis
- deactivates = glycolysis
2
Q
insulin activates/ deactivates
A
- activates = glycolysis
- deactivates = gluconeogenesis
3
Q
glucagon activates/ deactivates
A
- activates = gluconeogenesis
- deactivates = glycolysis
4
Q
regulation of hexokinase
A
- controlled by feedback inhibition of G6P
5
Q
regulation of glucokinase
A
- regulated by substrate = amount of glucose present
- cytosolic enzyme
6
Q
regulation of G6Pase
A
- controlled by substrate = amount of G6P present
7
Q
activity of glucokinase and G6Pase depends on
A
- concentration of glucose and G6P [whichever is higher]
8
Q
PFK-1 de/ activated by
A
- activated by = AMP and F26BP
- deactivated by cAMP = activates protein kinase A which activates F26BPase
9
Q
function of F26BPase
A
- chops up F26BP = decreases activity of PFK-1 and inhibition of F16BPase
10
Q
F16BPase de/activated by
A
- activated = cAMP
- deactivated = AMP and F26BP
11
Q
when insulin activates a protein [glycolysis]
A
- protein activates protein phosphatase A = activates PFK-2 = synthesizes F26BP = activates PFK-1 and inhibits F16BPase
12
Q
when glucagon degrades F26BP, PFK-1 is ___
A
- unbound and can be attacked by ATP/ citrate
13
Q
regulation of pyruvate kinase
A
- feedforward activation by F16BP and feedback inhibition by ATP
14
Q
pyruvate kinase de/activated by
A
- activated = insulin
- deactivated = glucagon
15
Q
pyruvate carboxylase activated by
A
- acetyl-CoA
