Lecture 30 - How and why infections happen Flashcards
where do infections come from
endogenous or communicable
Normal microbial flora
vary according to site
Upper airways – saliva 10^8 -10^9 bacteria per ml
GI tract – faeces 10^11 -10^12 bacteria per gram
Endogenous infection
Normal flora: Skin Gut Upper airways Genital tract Normal gut flora gets into wrong place Urinary tract infection e.g. cystitis
Cystisis
Infection of lower urinary tract Lower abdominal pain Urgency Dysuria Frequency
What bacteria is the most common cause of cystisis
gut flora
eg. eschericia coli
e coli - gram negative
where do communicable infections come from
person to person
non - human - animals/birds/insects
-environment
How do we get infections endogenously
migration
perforation
blood
How do we get infections exogenously
contact - direct and indirect injuries - trauma and bites airborne oral - food/water blood-borne sex mother- baby
Endogenous infection - what is migration
Bowel flora - E.coli contaminates perineum -gains access to urethra causes local infection spreads to bladder and beyong UTI
Endogenous infection - what is perforation
Diseases of bowel especially colon e.g.
Cancer
Diverticular disease
perforation leads to contamination of abdominal cavity by faecal flora
-severe life-threatening infection results - faecal peritonitis
Endogenous infection - what is blood spread
dental work - may allow mouth flora to enter blood stream
circulation of organisms allows them to reach distant sites eg. heart valve
-invasion can occur especially if valve tissue is abnormal - eg defect
causes inflammation and structural damage
Exogenous infection: direct contact
Impetigo
superficial skin infection due to staphylococci and/or streptococci
spreads rapidly from person to person
Exogenous infection: indirect contact
Micro-organisms can be transmitted indirectly via hands, equipment, furniture etc
Major route of health-care associated infections
- methicillin-resistant staphylococcus aureus (MRSA)
- Clostridium difficile
- Norovirus gastroenteritis
Injuries – dirty wound
Tetanus (Lockjaw) Clostridium tetani Bacterium present in soil Contaminates wounds Releases toxin causing muscle spasm Prevented by vaccination
Bites
malaria
- parasite infection
- life-cycle
- mosquitoes and humans
- present in large areas of tropics
- causes severe febrile illness affecting all systems
Airborne infection examples
influenza virus
- coughing and sneezing
- droplets formed containing infectious viruses
- inhaled by others
oral route - food bourne
Food prepared with poor hygiene E.g. not washing hands after going to toilet Contaminate food with harmful bacteria Result: food poisoning! Vomiting, diarrhoea
Blood -borne infection
hep B -liver infection -some viruses spill into blood -transmission by blood exposure -transfusion sharing of needles -body piercing