Lecture 3 - Respiratory 1 Flashcards
- Identify the anatomical structures located in the conducting and respiratory zones and describe the major function of each zone.
• Conducting Zone
Trachea
Incomplete* cartilage rings
Prevents airway collapse
Allows expansion of oesophagus
*Birds – complete cartilage rings
- Identify the anatomical structures located in the conducting and respiratory zones and describe the major function of each zone.
• Conducting Zone
Bronchi
Two primary bronchi
Branches into narrower tubes (secondary & tertiary)
Bronchi contain supportive cartilaginous plates
Mucus escalator to clean air
- Identify the anatomical structures located in the conducting and respiratory zones and describe the major function of each zone.
• Conducting Zone
Bronchioles
<1mm in diameter
Contain smooth muscle
No cartilage
Mucus escalator
- Identify the anatomical structures located in the conducting and respiratory zones and describe the major function of each zone.
• Conducting Zone
Terminal Bronchioles
Last anatomical structure in the conducting zone
- Identify the anatomical structures located in the conducting and respiratory zones and describe the major function of each zone.
• Respiratory Zone
Contain alveoli pockets
- Identify the anatomical structures located in the conducting and respiratory zones and describe the major function of each zone.
• Respiratory Zone
Sac like structures involved in gas exchange
- List the cells of alveoli and how they assist in respiration.
Type I
Alveolar cells
Pneumocytes form the structure of alveoli
Very think cells for gas exchange
- List the cells of alveoli and how they assist in respiration.
Type II
Alveolar cells
Synthesise surfactant that reduces the surface tension in alveoli
3. List the cells of alveoli and how they assist in respiration. Alveolar pores (of Kohn)
Equalise pressure between alveoli
- List the cells of alveoli and how they assist in respiration.
Alveolar Macrophages
Patrol the inner surfaces
Ingest small foreign particles
- Explain the effect of surfactant on alveolar surface tension and ventilation, and the problems that occur if surfactant is not produced.
• Secreted by type II pneumocytes • Reduces cohesive forces between h2o molecules • Lowers the surface tension - Increases lung compliance - Allows lungs to easily expand - Reduces work of breathing - Increases stability of lungs • Separates air from blood • Comprised of: - Type I alveolar epithelial cell - Basement membrane - Capillary endothelial cell
- Briefly describe the anatomical structure of the intrapleural space and the importance of intrapleural fluid.
• Structures:
- Double walled sac
- Pleura is the lining made from a single layer of squamous epithelial cells and connective tissue
- Visceral pleura covers the lungs
- Parietal pleura lines the thoracic wall
• Intrapleural fluid:
- Provides lubrication
- Friction free movement
- Generates surface tension
- Prevents separation of pleurae
- Holds lungs against chest in semi-inflated state
- Differentiate between anatomical and alveolar dead space and explain how these affect ventilation
• Anatomic dead space: - Volume of conducting zone • Alveolar dead space - Dead space within the respiratory zone - Alveoli unavailable for gas exchange • Anatomic + alveolar DS = physiologic DS - In animals this is minimal
- Explain the effect of exercise on the tidal volume: dead space ratio
• Faster breathing
- Increasing respiratory rate (RR) means shallower breathing increasing
• Deeper breathing
- Increasing deep breathing is more effective as this reduces faster breathing
- Maximises ventilation
• Fraction of each breath that ventilates dead space
• With exercise – dead space volume does not change significantly, but tidal volume increases and dead space volume/tidal volume decreases
- Describe the major structures of the upper and lower respiratory tract and explain their function.
• Upper tract
Nasal Cavities
Structure: Ciliated epithelium, mucus-producing goblet cells, cilia hairs
Function: Low resistant pathway during blockage/exercise