Lecture 3: Poisonous Vascular Plants Flashcards

1
Q

What part of monkshood is poisonous?

A

all! but especially roots and tubers

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2
Q

what is the poison of monkshood?

A

rapid-acting alkaliod aconitine

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3
Q

What are symptoms of monkshood poisoning?

A

tingling and numbness of the muscles, a staggaring gait, a crawling sensation on the skin, nausea, vomiting, laboured breathing, and an irregular pulse

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4
Q

what happened concerning monkshood in ancient greece?

A

infirm men on the Aegean island of ceos were condemned to drink an infusion of monkshood

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5
Q

what was the closely related Himalayan monkshood known in India as Bikh or nabee used for?

A

to poison well water in a n effort to stop advancing armies

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6
Q

When was monkshood used medicinally?

A

1800s and 1900s

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7
Q

What was a tincture of monkshood used for?

A

to diminish the pulse and to releice the poain associated with neuralgia, pleursy and aneurisms

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8
Q

where were related species of Aconitum used medicinally?

A

China and India

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9
Q

What family is monkshood a member of?

A

the buttercup family, Ranunculaceae

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10
Q

what family if poison hemlock a member of?

A

Carrot, Apiaceae family

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11
Q

who chose to be executed by drinking an infusion of poison hemlock?

A

ancient greek philosopher Socrates

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12
Q

who mentions properties of poison hemlock in his plays?

A

shakespeare

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13
Q

What are the active poisons in poison hemlock?

A

pyridine alkaloids including coniine and related compounds

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14
Q

what does coniine do?

A

stimulates and then paralyses the nicotinic receptors of the central nervous system.

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15
Q

what occurs in large doses of coniine?

A

acts as a powerful depressant causing neuromuscular blockage, paralysis, and a dangerous lowering of blood pressure. Death may result from collapse of the cardiovascular system.

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16
Q

what family does the water hemlock belong to?

A

carrot, Apiaceae
It includes three poisonous herbaceous sp. C. virosa (native to Europe), c. maculata (native to North America), and D. douglasii (native to the pacific north America

17
Q

what is the poison of water hemlock?

A

Acetylenic alcohol known as cicutoxin

18
Q

where do the highest concentration of cicutoxin of water hemlock occur/

A

taproot - which looks like a parsnip

19
Q

why do most cases of water hemlock occur?

A

purposeful ingestion of “wild parsnips”

20
Q

What is cicutoxin and what does it act on ?

A

its is a powerful convulsant and acts on the central nervous system

21
Q

what are the symptoms of water hemlock poisoning and when do they occur?

A

30 min following ingestion - include vomiting and convulsions, severe seizures, periodic cessation of breathing, and at high doses death

22
Q

what is castor oil used for?

A

as a laxative - but consumption of the whole seed or anything but the oil is fatal

23
Q

what is the toxic principle of the castor bean?

A

ricin - an extremely poisonous lectin

24
Q

what is a lectin

A

plant glycoprotiens with actions resembling those of a specific antibody e.g. agglutination and precipitation

25
Q

why are lectins not true antibodies?

A

because they do not require an anitgenic stimulus

26
Q

what does ricin cause?

A

it is rapidly absourbed by the gastrointestinal tract and causes agglutination and hemolysis of red blood cells. It causes severe haemorrhaging, gastrointestinal swelling, kidney degeneration and death

27
Q

where does ricin rank on the federal bureau fo investication list of toxic subtances?

A

3rd, after plutonium and botulism toxin

28
Q

ricin compared to cyanide and rattlesnake venom..

A

6000X more toxic than cyanid and 12000X more toxic than rattle snake venom

29
Q

how much ricin can kill half a million people?

A

130 g

30
Q

how much ricin killed georgi markoce in 1978

A

250 µg

31
Q

what is the rosary pea traditionally used for?

A

beading, including traditional caltholic rosaries

32
Q

what is the principal toxin in rosary pea?

A

abrin - a lectin simialr in structure and mode of action to ricin
It is more biologically toxic than ricin but less dangerous because it is absorbed much more slowly

33
Q

Anti-terrorism experts have expressed concern …

A

that palnt lectins could be used as biological weapons; they can be administered as powders, mists, or pellets and can be dissolved in water