Lecture 3: Pharmacology in Dermatology Flashcards
1
Q
Factors affecting topical absorption
A
Base/vehicle Concentration Chemical properties of drug Skin site Temperature Occlusion Thickness Hydration of stratum corneum
2
Q
Types of vehicle
A
Solution Cream Paste Spray powder Shampoo Ointment Foams Tape Gel Paint Lotion
3
Q
Drug used topically
A
Corticosteroids Antibiotics Antiviral Dithranol Chemotherapy Parasitidals Coal Tar Anti inflammatory drugs Salicylic acid
4
Q
Side effects of topical steroids
A
Thinning Stria Bruising Hirsutism Telangiectasia Steroid induced rosacea
5
Q
Types of systemic treatments in dermatology
A
Retinoids:
- Vitamin A analogues that normalise keratin function- highly teratogenic & cause dry skin/lips
Used in:
- Acne
- Psoriasis
- Cutaneous T-Cell lymphoma
- Hand eczema
Traditional immunosuppressants
e.g. MFF
Biologics (immunosuppressive)
- Target different inflammatory pathways
