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Immuno > Lecture 3 - Lymph Tissue > Flashcards

Lecture 3 - Lymph Tissue Flashcards

1
Q

Primary Lymph Tissue FXN & Organs

A

-Maturation of WBCs
Bone Marrow
Thymus

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2
Q

Secondary Lymph Tissue FXN & Organs

A 
-Activation of Lymphocytes
Lymph Nodes
Spleen
MALT
Tonsils
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3
Q

Location of hematopoesis fetal to adult

A

Yolk sac
Liver/Spleen
Bone Marrow

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4
Q

Red Marrow

A
  • location of hematopoiesis
  • filled w/ stromal cells, HSC, fibroblasts
  • Site of B, NK maturation
  • Site of T cell formation
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5
Q

Thymus Stromal Cells

A

Macrophages
Dendritic Cells (Conventional)
Thymic Epi Cells

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6
Q

Thymus is site of?

A

T cell maturation/differentiation

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7
Q

B Cell Location in Lymph Node

T Cell Location in Lymph Node

A

Follicle (b cell)

Paracortex (t cell)

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8
Q

Thymus gross structure?

A

Cortex & Medulla

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9
Q

Lymphocyte entrance into lymph node?

A
  • Via HEV (if from blood)

- Afferent vessel (if bound antigen in tissue)

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10
Q

Lymphocyte exit from lymph node?

A

Efferent vessel

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11
Q

Swollen lymph nodes due to?

A

Bacterial or viral infection (normally)

Allergic reaction, arthritis, cancer (possible causes)

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12
Q

Lymph flows from thoracic duct into?

A

Subclavian V.

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13
Q

Spleen (red vs. white pulp)

A

Red - phagocytosis RBC, antigens, microbes

White - lymph tissue

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14
Q

B Cell Location in Spleen

T Cell Location in Spleen

A

Follicle (b cell)

Periarteriolar lymphoid sheath (PALS) (t cell)

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15
Q

Spleen Gross Structure

A

Encapsulated organ w/ white and red pulp zones

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16
Q

Spleen Gross Function

A

Filter blood and remove antigen, microbes, old RBC

17
Q

Asplenia at risk for?

A

Infection, normally via ENCAPSULATED bacteria

18
Q

MALT & Tonsil FXN & Structure

A
  • Defend Mucosal Surfaces
  • collections of fibroblasts & WBCs
  • MALT (loose) uncapsulated
  • Tonsils - partially capsulated
19
Q

Steps of Cell Migration

A

Extravastation
-movement of WBC thru vessel wall into tissue (uses integrins & selectins)
Chemotaxis
-Directed movement via chemokines

20
Q

B Cell Migration to 2 Lymph Organ

A
  • CXCL13 secreted from follicular dendritic cells (FDCs)

- CXCR5 binds CXCL13 & guides via chemotaxis

21
Q

T Cell Migration to 2 Lymph Organ

A
  • CCL19 & CCL21 secreted from stromal cells of T zone

- CCR7 binds CCL19 & CCL21 & guides via chemotaxis

22
Q

Lymphocytes are constantly circ. btw blood & 2 lymph structures. How?

A
  • spleen via blood vessels

- Lymph node, HEV in and lymph system to subclavian v. out

Immuno (5 decks)

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