Lecture 3: Leading Causes of Mortality, 0-5 Years Flashcards

1
Q

What are the leading causes of mortality in the developing world for ages 0-5?

A
  1. Perinatal/neonatal conditions
  2. Lower respiratory infections
  3. Diarrheal diseases
  4. Malaria
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2
Q

What are the leading causes of mortality in the developed world for ages 0-5?

A
  1. Perinatal/neonatal conditions
  2. Congenital anomalies
  3. Lower respiratory infections
  4. Unintentional injuries
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3
Q

What makes up the perinatal time period?

A

Period from later half of pregnancy (22 weeks) through the first week after birth.

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4
Q

What makes up the neonatal time period?

A

First month after birth

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5
Q

What are the common peri/neonatal conditions?

A
  • Birth trauma/Obstructed/Prolonged Labor
  • Preterm birth/low birth weight
  • Birth asphyxia
  • Infections
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6
Q

What can prevent prenatal conditions?

A
  • Proper nutrition and prenatal care

- Skilled healthcare workers

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7
Q

Lower Respiratory Infection - Pneumonia

A

Explain how if infects, its diagnosis (x-rays & direct fluorescence assay)

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8
Q

What are the difference between diagnosis of pneumonia in the developed and developing world?

A

Developed

  • X-rays
  • DFA

Developing

  • Coughing
  • Rapid breathing
  • Cyanosis (blue nailbeds)
  • Chest indrawing
  • Sometimes x-rays
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9
Q

Pneumonia: Treatment

A

Depends on if viral or bacterial.

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10
Q

Pneumonia: Prevention

A
  • Vaccine
    • Hib, PCV,
  • Cleanliness
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11
Q

What are the 4 types of diarrhea and their causes?

A

Osmotic (water is drawn into the lumen), Secretory (water is being secreted into the lumen), Inflammatory (caused by infection), Motility (accelerated GI tract time)

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12
Q

Diarrheal Disease: Cholera

A

Extreme loss of water, can lead to death in 1 day if nor properly treated

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13
Q

Cholera: Treatment

A

Oral Rehydration Therapy (ORT): specific mixture of water, salt, and sugar. Although it is less expensive that IV therapy, not used clinically.

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14
Q

Rotavirus Vaccine

A

Many children infected with rotavirus, can cause vomiting making ORT difficult to administer (although still affective)

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15
Q

Malaria

A

Spread by mosquitos carrying parasite that infects humans. You should understand the life cycle.

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16
Q

Malaria: Pathagenisis

A

Symptoms: Fever, headaches, vomiting, anemia

Fatal disease:

  • anemia
  • cerebral anemia

Malaria can be transmitted across the placenta leading to still births

17
Q

Malaria: Prevention

A
  • Pregnant women and infants should sleep under insecticide
    treated nets (must be regularly retreated)
  • Reduced human/insect contact
  • Vaccines:
    There is a current leading vaccine, RTS and in August 2013 there was a new vaccine.
18
Q

Malaria: Drug Treatments

A
  • Chloroquine
  • Relatively inexpensive
  • Malaria parasite now show resistance
19
Q

Malaria Vaccine: August 2013

A

whole sporozoites weakened, requires multiples doses, most tested were protected with minimal side effects

20
Q

Congenital Anomalies

A

2-3% born with birth defects, leads to about 400,00 deaths

21
Q

Congenital Anomalies: Cuases

A

Causes are usually multifactorial, brain anomalies most common, heart anomalies most deadly

22
Q

How is the risk of congenital anomalies reduced?

A
  • Ultrasound imaging
  • Maternal malnutrition
  • Reduced environmental exposure
  • Lower age of pregnancy
23
Q

Unintentional Injuries: Cuases

A

Drowning and traffic accidents