lecture 3 (kinetics) Flashcards
1
Q
describe oral administration
A
- Relatively safe, convenient and economical (highest level of compliance)
- GI tract/liver in general is set up to break things down (lots of barriers)
2
Q
Describe sublingual/buccal administration
A
- Allows for LIPID SOLUBLE drugs to be absorbed across the oral mucous membrane and directly into venous blood (bypass first exposure to liver)
–> irritation of guns etc and can be uncomfortable
- AVOIDS METABOLISM BY LIVER
3
Q
describe rectal administration
A
- Allows delivery to an unconscious or vomiting patient
–>Not the most compliant way
- Allows for half of drug to avoid metabolism by liver; but can cause significant irritation
–> Rarely can get full absorption
4
Q
describe Intravenous administration
A
- Direct placement into the vein
- Rapid administration, bioavailability reaches 100% accurate dosing BUT no recalling the drug
5
Q
A
6
Q
describe intramuscular admnistration
A
- Direct injection into muscle
–> Dosing is usually less frequent (once a month)
- Exercise and fat distribution can significantly impact absorption
7
Q
Describe subcutaneous administration
A
- Method allows for constant absorption at a relatively slow rate
–> Decrease frequency, can be painful and can causes changes in the tissue.
8
Q
describe Intrathecal administration
A
- Administration via an injection into the subarachnoid space
- Delivery of drugs into the central nervous system
9
Q
describe transdermal administration
A
- Application to the skin
- More lipophilic will have greater success in penetration (lots of variability in amount of drug delivered
–> Avoids first pass through the liver; but difficult to make it through the skin
10
Q
describe inhalational administration
A
- Gaseous drugs across the pulmonary epithelium and mucous membranes
–> Goes directly to the heart (good or bad if toxicity)
- Allows for extremely rapid drug absorption
