Antiemetic agents Flashcards
1
Q
Ondansetron
A
5-HT3 ANTAGONIST
- inhibits the emetic response
-
2
Q
Scopolamine
A
M1 ANTAGONIST
- Inhibits the emetic response
- TX for MOTION SICKNESS
3
Q
Metoclopramide
A
D2 ANTAGONIST
- TX for: chemo and radiation therapy induced nausea/vomiting
- ADVERSE EFFECTS = Parkinsonian symptoms
4
Q
Dimenhydrinate
A
H1 ANTAGONIST
- TX for Motion sickness
- Adverse effects = Drowsiness
5
Q
Aprepitant
A
NK1 antagonist
- antiemetic
- Used in chemotherapy
6
Q
Prochlorperazine
A
M1, D2, H1 ANTAGONIST
NONSELECTIVE
- Used in severe nausea and vomiting; When everythign else fails.. target everything.
7
Q
Lorazepam
A
GABA agonist (indirect regulator)
–> causes suppression of neuronal firing
- TX for anxiety/chemotherapy induced emetic response
- Adverse effect = drowsiness
8
Q
nabilone
A
Cannabinoid agonist
- agonist to receptors in the brain that control emetic response
- TX for chemotherapy
- Adverse effects: dysphoria, sedation, increased appetitie
9
Q
Dexamethasone
A
Glucocorticoid agonist
- doesnt have direct effect, but increases effects of serotonin antagonist
- TX for: chemotherapy, postoperative
- Adverse effects: weight gain, water retention
10
Q
what are the key emetic receptors in the vestibular
A
- H1 –> dimenhydrinate
- M1 –> Scopolamine
11
Q
What are the main emetic receptors in the chemoreceptor trigger zone
A
- D2 –> Metoclopramide
- NK1 –> aprepitant
- 5-HT3 –> ondansetron
12
Q
what are the main emetic receptors in the solitary tract nucleus (vomiting center)
A
- M1 –> scopolamine
- H1 –> dimenhydrinate
- NK1 –> aprepitant
- 5-HT3 –> ondansetron
