Lecture 3: ADHD Flashcards

1
Q

ADHD Past & Present Diagnoses

A

1917- Post Encephalitic Behavior Disorder

1940-1950-Minimal Brain Dysfunction (MBD)

1960’s – Hyperkinetic Reaction of Childhood

  • there was a type of “ping-pong” effect that occurred in the scientific community, varying between which aspect seemed more dysfunctional, inattention or hyperactivity
    • Inattention is really what impedes progress at school, which led to the focus on attention deficits…

1970– Attention Deficit Disorder (ADD)
*Specifiers – With/without Hyperactivity

1980-Present: Attention Deficit / Hyperactivity Disorder (ADHD)

*The slash is critical, as it denotes that both aspects do not necessarily present together.

*Previously, it was thought that the presentation will generally stay the same at different ages, but increasing
evidence was mounting that different presentations occur different developmental stages

*With the DSM-5, it is “presentations” instead of subtypes
Inattention (IN); Hyperactive-Impusive (HI); Combined

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2
Q

Prevalence of ADHD

A

3-9% of elementary school population, may range up to 14%

More common in males than females, ranging from 4:1 to 9:1

One of the most common disorders of childhood
*this is possibly due to ADHD being an easy “go-to” diagnosis, with the thinking that if the diagnosis is wrong, there is plenty of time to reevaluate and re-diagnose later

accounts for a large number of medical and mental health referrals

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3
Q

Diagnostic Criteria for ADHD

A

Symptom Criteria

  • core symptoms of hyperactivity and impulsivity and/or inattention
  • 6 or more symptoms of either category

Duration Criterion
*symptoms have persisted for at least six months

Developmental Criterion
*symptoms are inconsistent with developmental level

Impairment Criterion

  • clear evidence of clinically significant impairment in social, academic, or occupational functioning
  • *this might be the most important criterion, as behavior is deemed pathological primarily when it creates impairment in functioning

Age Criterion

  • some symptoms that cause impairment were present before age 12 (previous age was 7)
  • *in general, it is tough to diagnose the very young due to developmental considerations, diagnosis is rarely given before age 3-4

Situation Criterion

  • some impairment from symptoms is present in multiple settings
  • *sometimes the symptoms only exist in school settings – not necessarily ADHD

Exclusion Criterion
*psychotic disorder or other mental disorder

Specifier
*“in partial remission” included for adolescents-adults with symptoms but not meeting full criteria

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4
Q

Major Changes to DSM-5

A

Change from three subtypes into three specifiers:

  • combined presentation
  • predominantly inattentive presentation
  • predominantly hyperactive/impulsive presentation

ADHD across the lifespan: more examples were added to increase applicability to adults

Changing age of onset to 12 (formerly 7)

Removed autism from exclusion criteria
*e.g. twins with autism, boy with ADHD, climbing on everything, eating purell

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5
Q

DSM-5 Symptoms of Hyperactivity

A

Often fidgets with hands or feet, squirms in seat
*e.g. video of interview with Jack, five-year-old boy

Often leaves seat in classroom or in other situations in which remaining seated is expected

Often runs about or climbs excessively in situations in which it is inappropriate

Often has difficulty playing or engaging in leisure activities quietly. Is often “on the go” or often acts as if “driven by a motor”

Often talks excessively when inappropriate to the situation

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6
Q

Hyperactivity, general

A

Children with ADHD are more active, restless and fidgety than normal children during the day AND during sleep

different types of hyperactivity:

  • gross motor activity
  • restless/squirmy
  • occasionally there is a form of verbal hyperactivity

Hyperactivity often varies according situation

Degree of hyperactivity may vary with age

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7
Q

DSM-5 Symptoms of Impulsivity

A

often blurts out answers before questions have been completed

often has difficulty awaiting turn

often interrupts or intrudes on others

*Six symptoms of hyperactivity AND impulsivity are required for diagnosis

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8
Q

DSM-5 Symptoms of Inattention

A

Often has difficulty organizing tasks and activities

Often avoids, dislikes or is reluctant to engage in tasks that require sustained mental effort

Often loses things necessary for tasks or activities

Is often easily distracted by extraneous stimuli

Is often forgetful in daily activities

Cross-situational
*instead of separate section, specifiers/symptoms were added that were more relevant to adults (e.g. workplace)

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9
Q

Attention, general

A

The greatest difficulties are with sustaining attention, being vigilant

  • playing video game for 4 hours is not an example of paying attention – a child with ADHD is able to do this, as it is exciting and engaging
  • What a child with ADHD is not able to to is sustained attention when the task takes effort, when is something that they do not want to do…

Most clearly seen in situations requiring the child to attend over time too dull, boring and repetitive tasks

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10
Q

Theoretical Considerations 1970s-present

A

“Top Down” theories – cognitive control
*Barkley–deficits in rule governed behavior and response inhibition

“Bottom Up” theories – motivational/energetic factors (it may be more intrinsically rewarding to be impulsive)
*Sagvolden – reinforcement gradient

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11
Q

Sluggish Cognitive Tempo (SCT)

A

Dr. Ohr: “presentation of a presentation”

Subset of children with predominantly inattentive presentation who show few or no symptoms of hyperactivity or impulsivity

*forgetful

  • daydreams, sluggish/slow to respond, drowsy/sleepy
  • **Not explained by depression
  • easily confused
  • seems to be “in a fog”
  • stares into space
  • acts overtired
  • underactive/lacks energy
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12
Q

ADHD Proposed Developmental Progression

A

Difficult infant temperament as early precursor

Initial development of ADHD most often during preschool years

*tentative to diagnose until later due to potential conflicting developmental factors

Decline in level of activity and improvement in attention and impulse control in adolescence, but 80% still continue to meet diagnostic criteria

*it shows up in different ways: sexual promiscuity, alcohol/drug use, rule breaking behaviors (truancy, stealing, sexual assault)

**these behaviors are simply more likely, not a destined path for children ADHD, just one of the paths that have been clearly documented

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13
Q

Etiology: Biological Risk Factors

A

Genetics
*.80 heritability with twins, 50+ risk if parent has diagnosis, dopamine type 2 gene

Neurological Insults – anoxia, seizure disorders, encephalitis

Neurotransmitter deficiencies – – decrease the risk of economic

Anatomical atypicalities – smaller corpus callosum

Cerebral blood flow – decreased to prefrontal and frontal regions and pathways

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14
Q

Etiology: Psychosocial Factors

A

Less evidence for psychosocial factors

Parent-child conflict may exacerbate problems

Lack of consistent parenting strategies, poor limit setting

However, psychosocial factors may contribute to development of comorbid disorders that may complicate the clinical picture

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15
Q

ADHD Prognosis in Adulthood

A

As many as 67% of children with ADHD display symptoms in adulthood serious enough to interfere with academic, vocational or school functioning

Type of ADHD that persist into adulthood is more highly genetic than type that remits and childhood
*the younger the presentation of any pathology, the more likely it will persist

ADHD in adults is sometimes considered a “hidden disorder” as symptoms are often obscured by other problems

Prevalence is thought to be 2 to 4% with sex ratio of 2:1 or lower

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16
Q

ADHD Common Comorbid Conditions

A

Prevalence, high to low:

Oppositional Defiant Disorder

Anxiety Disorder

Mood Disorder

Learning Disorder

Conduct Disorder

17
Q

Recent Changes in Defining ADHD:

4 Executive Functions (Barkley)

A

Prolongation
Separation and Regulation of Affect
Internalization of language
Reconstitution

Prolongation: Holding and evaluating events in working memory
* unable to bring rules/consequences to mind in the moment

Separation and Regulation of Affect: Splitting facts from feelings

Internalization of language: Reflection, self-control, willpower

Reconstitution: Break events into parts and reassemble into new ideas

18
Q

Barkley’s Research Validating Executive Function Deficits

A

Children with ADHD have difficulty with:

  • inhibiting behavioral responses
  • working memory
  • planning and organization
  • verbal fluency
  • perseveration
  • motor sequencing
  • various frontal lobe functions
19
Q

Issues and Controversies

A

Overmedicated/Overdiagnosed?

Allen Frances:
Will changes to DSM-5 trigger a fad of adult ADHD “leading to widespread misuse of stimulant drugs for performance enhancement and recreation and contributing to the already large illegal secondary market in diverted prescription drugs”

After much consideration, “inattentive restrictive presentation” was not included

  • this category would have reflected SCT – no impulsivity, no hyperactivity
  • *Dr. Ohr was very surprised to learn of its omission

Comorbidity with bipolar disorder (impulsive behavior very common with BPD) & ODD

Are there other ignored subtypes? (SCT)

What about diagnosis prior to age 4?

20
Q

General Lecture Notes / Considerations

A

ADHD YouTube video (boy on roller skates)

Certain lyrics were very representative of disorder:

*his actions occurred unintentionally – however, it is common to see children become oppositional and perform intentional defiant acts following unintentional outbursts

Executive Functioning

*children are unable to bring rules/ consequences to mind in the moment

Dr Ohr: this is just one piece of a very complex puzzle – EF has many different components, many factors at play – e.g. lack of NT’s, which decreases blood flow, producing a oxygen deprived environment

*or the consequence exists, but does not have the reinforcement power (e.g. understanding that by behaving a certain way will increase likelihood that others will want to play with you)

Difficulty Titrating Medications

*children are in constant physical development, as they go through growth spurts it becomes very difficult to maintain the proper level of medication

**Barkley: he started out as viewing meds as a last resort, but shift in thinking is growing evidence pointed to ADHD as a neurodevelopment disorder (where it is now classified in the DSM-5)

21
Q

Treatment of ADHD

A

Stimulant Medications

Other Medications

Psychosocial Treatments

Educational Accommodations

22
Q

ADHD: Commonly Used Stimulant Medications

A

Ritalin

Dexedrine

Adderall

Concerta

Between 70 to 80% of children with ADHD respond positively to stimulant drugs

23
Q

Side Effects of Stimulants

A

Loss of appetite, weight loss, sleeping problems, irritability

Restlessness, stomachache, headache, rapid heart rate, elevated blood pressure, sudden deterioration of behavior

Symptoms of depression with sadness, crying, and withdrawn behavior

Intensification of tics, possible Tourette’s and growth suppression

Side effects usually transient in nature and result of inappropriate medication levels

If one medication results in side effects, another might be used without side effects

Sometimes other medications are used to minimize side effects

Good clinical judgment by the clinician may help to minimize side effects

24
Q

NonStimulant Drugs in ADHD Treatment

A

Strattera
norepinephrine reuptake inhibitor

Antidepressants (e.g.Tofranil, Wellbutrin)

Anti-hypertensives (Clonidine)

25
Q

ADHD Psychosocial Treatments

A

Parent training

Behavioral management

Social skills training

Cognitive behavioral therapy

Psychotherapy for comorbid conditions

26
Q

ADHD Educational Interventions

A

Special Education Services for existing learning problems

Classroom accommodations

Classroom behavior modification programs

27
Q

Multimodal Treatment for ADHD

A

In treating ADHD it is essential to treat the full range of difficulties that impact on child and family functioning

Treatment of ADHD will often need to be “multimodal” in nature

Findings from the multimodal treatment studies suggest that stimulant medication is effective in reducing core symptoms & psychosocial treatments are of value in addressing associated comorbidities

28
Q

Assessment of ADHD

A

Direct Observation–functional behavioral analysis

Parent, Teacher & Self-Reports

  • BASC –Behavior Assessment System for Children
  • CBCL–Child Behavior Checklist
  • Conners (Only test that includes Impairment measure)

Semi-Structured Interviews of Visual Attention
TOVA–Test of Variables of Attention

29
Q

Clinic-Based Diagnostic Assessments

A

Matching Figures Task

Continuous Performance Task (CPT)

*These do not facilitate differential diagnosis between ADHD, ODD, & CD–they do not correlate strongly with behavior rating scales

30
Q

Interventions / Treatments

A

Behavioral:
Patterson
*Parent Management Training

Eyberg
*Parent-Child Interaction Therapy

Webster-Stratton

  • Incredible Years
  • (based primarily on Patterson’s Coercion Hypothesis)

CBT:
Kazdin
*Problem-Solving Skills Training (PSST)
*PSST-P: Addition of in vivo Practice

Group:
ADHD Summer Treatment Program
*8 weeks, 8 hours/day, 5 days/week
*Parental involvement mandatory

MTA Cooperative Group
*combined treatment strategy